Aims: To define frequency and predictors of aborted myocardial infarctions (MI) after primary angioplasty.
Methods And Results: We analysed 196 consecutive patients with the clinical diagnosis of ST-elevation acute coronary syndrome (ST-ACS) admitted for primary angioplasty to one interventional facility between October 2005 and September 2006. Aborted MI was defined as a creatine increase of less than two times the upper limit of normal, combined with typical evolutionary electrocardiographic changes. Masquerading MI was diagnosed if evolutionary changes were missing or could be attributed to other causes. Thirty-four patients (17,3%) had an aborted and nine (4,6%) a masquerading MI. The main predictor of abortion was Thrombolysis In Myocardial Infarction (TIMI) flow 2 or 3 prior to procedure. The in-hospital mortality of aborted MI was 0%, the one year mortality 2.9%. Sixteen patients without prior or inter-current myocardial infarction had a preserved ejection fraction on cardiac MR at 12 months; in six patients even without any detection of late enhancement.
Conclusions: There is a substantial proportion of aborted myocardial infarction after primary angioplasty, corresponding to a small or even non detectable scar formation in terms of late enhancement on cardiac MR. Preprocedural TIMI flow 2 or 3 is the main predictor of aborted MI.
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http://dx.doi.org/10.4244/EIJV6I7A146 | DOI Listing |
Int J Cardiol Heart Vasc
February 2025
Department of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Germany.
Background: A significant number of patients with atrial fibrillation (AF) on direct oral anticoagulants (DOACs) receives off-label or inappropriate doses. This study examines the prevalence, dosages, and clinical outcomes in AF-patients on DOAC therapy admitted to an emergency department (ED).
Methods: This retrospective single-center observational study utilized data from the Heidelberg Registry of Atrial Fibrillation (HERA-FIB), consecutively including patients with AF presenting to the ED of the University Hospital of Heidelberg from June 2009 to March 2020.
Int J Cardiol Heart Vasc
February 2025
Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225000, China.
Background: Thrombolysis in Myocardial Infarction (TIMI) risk score in patients with ST-segment elevation myocardial infarction (STEMI) is associated with major adverse cardiovascular events (MACE). This study aimed to develop a prediction model based on the TIMI risk score for MACE in STEMI patients after percutaneous coronary intervention (PCI).
Methods: We conducted a retrospective data analysis on 290 acute STEMI patients admitted to the Affiliated Hospital of Yangzhou University from January 2022 to June 2023 and met the inclusion criteria.
Pak J Med Sci
January 2025
Ummu Tas, Associate Professor, Department of Cardiology, Izmir Demokrasi University, Goztepe, Izmir, Turkey.
Kounis syndrome also known as allergic myocardial infarction, represents the simultaneous occurrence of acute coronary syndromes with allergic or hypersensitivity reactions. We present a case of a 58-years-old male who developed anaphylaxis following a leech bite, leading to myocardial infarction despite the absence of prior allergic history. He was entubated and cardiopulmonary resusciation had been performed for 10 minutes.
View Article and Find Full Text PDFFront Pharmacol
January 2025
The Sixth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, The Fifth Affiliated Hospital, Guangzhou, China.
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide, and mitigating oxidative stress is crucial in managing MI. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a critical role in combating oxidative stress and facilitating cardiac remodeling post-MI. Here, we engineered Cerium oxide (CeO) nanoparticle-guided assemblies of ceria/Nrf2 nanocomposites to deliver Nrf2 plasmids.
View Article and Find Full Text PDFJACC Adv
February 2025
Department of Emergency Medicine, Hennepin County Medical Centre, and University of Minnesota School of Medicine, Minneapolis, Minnesota, USA.
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