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Finding a "NEW VOICE to tell my story" through the Unmasking Brain Injury project: a mixed-method analysis of wellness after brain injury.
Disabil Rehabil
January 2025
Courage Kenny Rehabilitation Institute, Allina Health, Minneapolis, MN, USA.
Purpose: This study aimed to explore the narratives of people with acquired brain injury (ABI) who participated in the Unmasking Brain Injury project. Through this inquiry, the multifaceted nature of wellbeing after ABI was described in the narratives, which were characterized by identifying facilitators and barriers to overall wellness.
Methods: A mixed-methods approach was utilized for this study.
Retina-on-chip: engineering functional models of the human retina using organ-on-chip technology.
Lab Chip
January 2025
Applied Stem Cell Technologies Group, Department of Bioengineering Technologies, University of Twente, Enschede, The Netherlands.
The retina is a complex and highly metabolic tissue in the back of the eye essential for human vision. Retinal diseases can lead to loss of vision in early and late stages of life, significantly affecting patients' quality of life. Due to its accessibility for surgical interventions and its isolated nature, the retina is an attractive target for novel genetic therapies and stem cell-based regenerative medicine.
View Article and Find Full Text PDFUnlabelled: Shortlisting is the task of reducing a long list of alternatives to a (smaller) set of best or most suitable alternatives. Shortlisting is often used in the nomination process of awards or in recommender systems to display featured objects. In this paper, we analyze shortlisting methods that are based on approval data, a common type of preferences.
View Article and Find Full Text PDFInsulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson's disease pathology.
J Tissue Eng
January 2025
Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Growing evidence indicates that type 2 diabetes (T2D) is associated with an increased risk of developing Parkinson's disease (PD) through shared disease mechanisms. Studies show that insulin resistance, which is the driving pathophysiological mechanism of T2D plays a major role in neurodegeneration by impairing neuronal functionality, metabolism and survival. To investigate insulin resistance caused pathological changes in the human midbrain, which could predispose a healthy midbrain to PD development, we exposed iPSC-derived human midbrain organoids from healthy individuals to either high insulin concentration, promoting insulin resistance, or to more physiological insulin concentration restoring insulin signalling function.
View Article and Find Full Text PDFTherapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing.
J Tissue Eng
January 2025
Department of Spinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Rotator cuff tendon injuries often lead to shoulder pain and dysfunction. Traditional treatments such as surgery and physical therapy can provide temporary relief, but it is difficult to achieve complete healing of the tendon, mainly because of the limited repair capacity of the tendon cells. Therefore, it is particularly urgent to explore new treatment methods.
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