Background/purpose: Age perception is based on a number of facial attributes such as wrinkles, skin gravity effects, feature lines, and skin optical appearance. The colorimetric and optical diffusion properties of skin have been compared with the consumer interpretation of 'skin age' of cheek area pictures without wrinkles or feature lines.
Methods: Controlled lighting images of skin were taken with the Visia CR. Skin sections from the cheek area were selected without eye region wrinkles or naso-labial lines for consumer interpretation. These same skin sections were analyzed for optical roughness and colorimetric parameters in the LCH color space, by distinguishing several roughness parameters according to their physical scale.
Results: Three main optical parameters of skin were found to influence the consumer's interpretation of skin 'visual age': the chroma (color saturation), lightness, and the local light-diffusing ability of skin. For the chroma and lightness, mainly large-scale inhomogeneities in the 0.8-2 cm(-1) range are taken into account by the consumer. Surprisingly, variations in the skin hue show a total absence of correlation with the consumer grading.
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http://dx.doi.org/10.1111/j.1600-0846.2010.00480.x | DOI Listing |
BMC Rheumatol
January 2025
Department of Rheumatology, Overton Brooks VA Medical Center, Shreveport, LA, USA.
Background: Dermatomyositis is a chronic inflammatory condition affecting muscles and skin, often associated with an increased risk of cancer. Specific autoantibodies, including anti-TIF1 (Transcription Intermediary Factor 1), have been linked to this risk. We present a case of dermatomyositis in a male patient positive for anti-TIF1 antibodies, subsequently diagnosed with squamous cell carcinoma of the tonsil, a novel association not previously documented.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Computer Science and Engineering, E.G.S. Pillay Engineering College, Nagapattinam, 611002, Tamil Nadu, India.
In response to the pressing need for the detection of Monkeypox caused by the Monkeypox virus (MPXV), this study introduces the Enhanced Spatial-Awareness Capsule Network (ESACN), a Capsule Network architecture designed for the precise multi-class classification of dermatological images. Addressing the shortcomings of traditional Machine Learning and Deep Learning models, our ESACN model utilizes the dynamic routing and spatial hierarchy capabilities of CapsNets to differentiate complex patterns such as those seen in monkeypox, chickenpox, measles, and normal skin presentations. CapsNets' inherent ability to recognize and process crucial spatial relationships within images outperforms conventional CNNs, particularly in tasks that require the distinction of visually similar classes.
View Article and Find Full Text PDFNPJ Breast Cancer
January 2025
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Endocrine therapy with CDK4/6 inhibitors is standard for estrogen receptor-positive, HER2-negative metastatic breast cancer (ER+/HER2- MBC), yet clinical resistance develops. Previously, we demonstrated that low doses of palbociclib activate autophagy, reversing initial G1 cell cycle arrest, while high concentrations induce off-target senescence. The autophagy inhibitor hydroxychloroquine (HCQ) induced on-target senescence at lower palbociclib doses.
View Article and Find Full Text PDFActa Med Indones
October 2024
Division of Tropical and Infection Diseases, Department of Internal Medicine, Medical Faculty of Universitas Sebelas Maret - Moewardi Hospital, Surakarta, Indonesia.
A 71-year-old man complained of a blackish wound under his left eye, which began with fever and reddish spots after helping to slaughter a cow and cut its meat. The fever occured especially in the afternoon to evening, and is not accompanied by chills and sweating. On day 4 of fever onset, the fever diminished and the spots progressively widened with swelling.
View Article and Find Full Text PDFLife Sci Space Res (Amst)
February 2025
Institute of Biomedical Problems of the Russian Academy of Sciences, 76A Khoroshevskoye shosse, 123007, Moscow, Russian Federation.
One of the most problematic goals for radiation safety during spaceflight is an assessment of additional doses received by astronauts during extravehicular activity (EVA). The Pille-ISS thermoluminescent dosimeter developed by the predecessor of the Hungarian Research Network (HUN-REN) Centre for Energy Research (Budapest, Hungary) is designed for the routine dose measurements not only inside the spacecraft compartments, but also for personal dosimetric control for EVA. During almost two decades of the International Space Station (ISS) operation, the unique set of 131 EVA doses were recorded in different conditions, such as: solar activity, ISS trajectory along the South Atlantic Anomaly (SAA), and shielding conditions provided by two kinds of spacesuits: the Extravehicular Mobility Unit (EMU) and Orlan.
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