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Gibberellin regulates the synthesis of stone cells in 'Nanguo' pear via the PuMYB91-PuERF023 module.
Physiol Plant
January 2025
Key Laboratory of Fruit Postharvest Biology, Liaoning Province; College of Horticulture, Shenyang Agricultural University, Shenyang, China.
Stone cells are one of the limiting factors affecting pear fruit quality and commodity value. The formation of stone cell is highly correlated with lignin deposition. However, the molecular mechanism of stone cell formation and regulation is still unclear.
View Article and Find Full Text PDFAcute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein.
Metab Brain Dis
January 2025
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, Room 10006, 60 Fenwood Road, Boston, MA, 02115, USA.
α-Synuclein (αS) is a 140 amino-acid neuronal protein highly enriched in presynaptic nerve terminals. Its progressive accumulation in Lewy bodies and neurites is the hallmark of Parkinson's disease (PD). A growing number of studies highlights a critical interplay between lipid metabolism and αS biology.
View Article and Find Full Text PDFApplication of fertilizers improves cadmium phytoextraction efficiency of Nasturtium officinale R.Br. grown in cadmium-contaminated water.
Environ Monit Assess
January 2025
School of Environmental Studies, China University of Geosciences, Wuhan, 430074, China.
Increasing toxic metal pollution in the aquatic ecosystem since the industrial revolution produces serious environmental challenges and has raised critical questions of ecological and human health implications. As a typical aquatic plant, Nasturtium officinale (N. officinale) has drawn significant attention due to its remarkable accumulation of heavy metals and other harmful substances from polluted water.
View Article and Find Full Text PDFEnhancing Photodynamic Therapy Efficacy via Photo-Triggered Calcium Overload and Oxygen Delivery in Tumor Hypoxia Management.
ACS Appl Mater Interfaces
January 2025
Department of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children's Hospital of Chongqing Medical University, Chongqing 400010, China.
: Photodynamic therapy (PDT) has emerged as a promising treatment for cancer, primarily due to its ability to generate reactive oxygen species (ROS) that directly induce tumor cell death. However, the hypoxic microenvironment commonly found within tumors poses a significant challenge by inhibiting ROS production. This study aims to investigate the effect of improving tumor hypoxia on enhancing PDT.
View Article and Find Full Text PDFColostrum-Derived Melatonin Plus PEG Microspheres Modulate the Oxidative Metabolism of Human Colostrum Phagocytes.
Metabolites
January 2025
Programa de Pós-Graduação em Ciência de Materiais, Campus Universitário do Araguaia, Universidade Federal de Mato Grosso, Barra do Garças 78605-091, Brazil.
Background/objectives: Exogenous melatonin adsorbed onto PEG microspheres can modulate the functional activity of phagocytes in colostrum, but no data are available on the activity of melatonin found in colostrum. Therefore, the objective of this study was to extract melatonin from human colostrum, develop and characterize PEG microspheres with the extracted melatonin adsorbed onto them, and evaluate the effects of this system on the oxidative metabolism of colostrum phagocytes.
Methods: Thirty colostrum samples were collected; ten were used for melatonin extraction, while twenty were used to obtain phagocytes.
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