Objective: To understand the role of leptin and adiponectin in obese asthmatics.
Methods: We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects.
Results: We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11).
Conclusion: Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.
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