Loading of mouse motor nerve terminals with EGTA-AM, but not with BAPTA-AM, inhibited the release of the neurotransmitter in response to stimulation of the nerve with rare (0.3 Hz) "single" pulses. During rhythmic stimulation with short (50 EPP) high-frequency (20 Hz) series, BAPTA-AM buffer modified burst pattern in a dose-dependent manner: it replaced the phase of initial facilitation by persistent depression of secretion and decreased its plateau level at the end of the burst. In contrast, loading of the nerve terminals with EGTA-AM buffer produced no effect on the phase of initial facilitation, but decreased the plateau level to the same degree as BAPTA-AM did. Probably, the different effects of both buffers on secretion of neurotransmitter reflect peculiarities of involvement of fast and slow Ca(2+)signals of motor terminals in single and rhythmic release of the neurotransmitter.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-010-0926-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phosphate rebinding induces force reversal via slow backward cycling of cross-bridges.
Front Physiol
January 2025
Institute of Vegetative Physiology, University of Cologne, Köln, Germany.
Objective: Previous studies on muscle fibers, myofibrils, and myosin revealed that the release of inorganic phosphate (P) and the force-generating step(s) are reversible, with cross-bridges also cycling backward through these steps by reversing force-generating steps and rebinding P. The aim was to explore the significance of force redevelopment kinetics (rate constant ) in cardiac myofibrils for the coupling between the P binding induced force reversal and the rate-limiting transition for backward cycling of cross-bridges from force-generating to non-force-generating states.
Methods: and force generation of cardiac myofibrils from guinea pigs were investigated at 0.
Immunosuppressive therapy and nutritional diseases of patients after kidney transplantation: a systematic review.
BMC Nephrol
January 2025
Department of Clinical Dietetics, Medical University of Warsaw, Erazma Ciolka 27 Street, Warsaw, 01-445, Poland.
Background: Kidney transplantation (kTx) is by far the most effective method of treating end-stage renal disease, with immunosuppressive therapy being obligatory for all, except identical twins. Despite kTx being the most effective treatment for end-stage renal disease, the patients face significant morbidity. They are often burdened with diabetes, anaemia, lipid disorders, all of which pose heightened risks for cardiovascular disease.
View Article and Find Full Text PDFThe effect of blood glucose levels on serum triglyceride clearance in patients with hyperlipidemic acute pancreatitis.
Sci Rep
January 2025
Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, No.1055, San-xiang Road, Gu-su District, Suzhou, 215000, China.
Preventing moderately severe and severe acute pancreatitis (MSAP & SAP) is the primary goal of the management of hyperlipidemic acute pancreatitis (HLAP). The main aim of this study was to investigate the factors affecting serum triglyceride (TG) clearance, particularly blood glucose (GLU) levels, which could potentially help to prevent the development of MSAP & SAP. The clinical data from 177 patients with MSAP & SAP and 195 patients with mild acute pancreatitis (MAP) on days 1-6 after the onset were collected and analyzed by multivariate logistic regression to identify the factors that have an impact on the severity of HLAP, especially TG.
View Article and Find Full Text PDFApplication of molten salt thermoelectric effect in biomass preparation of hydrogen-rich gas, porous biochar and molten salt regeneration.
Sci Total Environ
January 2025
State Key Laboratory of Coal Combustion, Huazhong University of Science and Technology, Wuhan 430074, China.
Hydrogen production from biomass pyrolysis is attractive since it allows for green hydrogen production through feedstock and thermal conversion. However, the key limiting factors for hydrogen production are the high oxygen content, uneven heating of biomass pellets during the slow heating process, and insufficient depolymerization due to low reaction temperatures (low gas yields and low hydrogen content). To address these challenges, fast pyrolysis of super Arundo in NaOH-NaCO molten salt was carried out in this paper at 450 °C, 550 °C and 650 °C.
View Article and Find Full Text PDFThe Rapid Transport of Excitons in Organic Crystals Can Be Regulated by the Molecular Packing Form.
J Phys Chem Lett
January 2025
College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.
Long-range exciton transport is crucial for optoelectronic devices based on organic semiconductors, but the method for increasing and regulating the exciton transport rate in organic semiconductors is still underexplored. Here we have achieved rapid-transporting excitons in organic crystals assembled of difluoroboron β-diketonate (BCZ) and found that the exciton transport rate of BCZ crystals can be regulated by the molecular packing form. Using transient absorption microscopy, we find that the BCZ-Y crystal in which BCZ molecules experience uniform head-to-tail antiparallel molecular packing has anisotropic long-range exciton transport.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!