Aim: The Dräger Babylog 8000plus ventilator (Dräger Medical Systems, Lübeck, Germany) can provide both conventional and high-frequency ventilation (HFV). Dräger recommends specific circuits for each of these modes. We investigated the performance of the Babylog ventilator in HFV mode when used with the recommended circuits for both conventional and HFV.
Methods: The Fisher and Paykel RT235 (conventional; Fisher and Paykel Healthcare, Auckland, New Zealand) and Hytrel (HFV; Fisher and Paykel Healthcare) circuits were studied using a 50-mL test lung. Tidal volume, high-frequency minute volume and ventilator alarms were compared at 100 combinations of mean airway pressures (10-16 cm H₂O), frequencies (6-14 Hz) and amplitudes (20-60%).
Results: Tidal volume with the two circuits differed by < 5% for tidal volumes ≤ 2.5 mL. Above this, tidal volumes delivered with the HFV circuit were up to 15% more than that obtained with the conventional ventilation circuit, and high-frequency minute volume differed by up to 30%. With the exception of the highest tidal/minute volumes, the tidal volume delivered using the HFV circuit could also be achieved with adjusted frequency or amplitude when using the conventional circuit. More 'pressure measurement out of range' alarms were noted with the conventional ventilation circuit, particularly at mean airway pressure ≥ 14 cm H₂O and frequency ≤ 10 Hz.
Conclusions: The conventional ventilation circuit may allow delivery of adequate tidal volume for some infants. Where requirements are higher, the HFV circuit allows the Babylog to deliver higher tidal volumes and higher minute volume, and reduce alarms.
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http://dx.doi.org/10.1111/j.1440-1754.2010.01946.x | DOI Listing |
Sci Rep
January 2025
Department of Mechanical Engineering, PSG Institute of Technology and Applied Research, Coimbatore, 641026, India.
Typical waveforms used for the simulation of pressure and volume-controlled ventilation in medical ventilators have been extensively studied in the literature. The majority of simulation studies reported employ the step pattern or ramp pattern to model the pressure and flow variations in pressure/volume-controlled ventilation. It was observed that the above waveforms tend to add to the discomfort level of patients due to the presence of jerks in derivatives of pressure/flow variations; the pressure/flow variation of air and oxygen mixture should be smooth so that the patient discomfort is kept at a minimal level.
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January 2025
Department of Respiratory Medicine, NHO Okayama Medical Center, Japan.
A 52-year-old Japanese man with a history of childhood asthma presented at our emergency department with progressive dyspnea. Despite subcutaneous adrenaline injections, salbutamol nebulization, and intravenous methylprednisolone, the carbon dioxide partial pressure (pCO) increased to 110 mmHg. The patient was intubated, and mechanical ventilation was initiated because of severe respiratory failure.
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January 2025
Department of Pathology, Dokkyo Medical University School of Medicine and Graduate School of Medicine, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Although alveolar hyperoxia exacerbates lung injury, clinical studies have failed to demonstrate the beneficial effects of lowering the fraction of inspired oxygen (FO) in patients with acute respiratory distress syndrome (ARDS). Atelectasis, which is commonly observed in ARDS, not only leads to hypoxemia but also contributes to lung injury through hypoxia-induced alveolar tissue inflammation. Therefore, it is possible that excessively low FO may enhance hypoxia-induced inflammation in atelectasis, and raising FO to an appropriate level may be a reasonable strategy for its mitigation.
View Article and Find Full Text PDFToxicology
January 2025
National Human Diseases Animal Model Resource Center, National Center of Technology Innovation for animal model, State Key Laboratory of Respiratory Health and Multimorbidity, NHC Key Laboratory of Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, CAMS & PUMC, Beijing, China. Electronic address:
The environmental impact of harmful particles from tire and brake systems is a growing concern. This study investigated the health impacts of PM emissions from brake pad wear on adult C57BL/6 mice. The mice were exposed to brake pad particles via intratracheal infusion, and various health parameters were assessed.
View Article and Find Full Text PDFAnesthesiology
January 2025
Takeda Development Center Americas, Inc., Lexington, MA, USA.
Background: Orexin neuropeptides help regulate sleep/wake states, respiration, and pain. However, their potential role in regulating breathing, particularly in perioperative settings, is not well understood. TAK-925 (danavorexton), a novel, orexin receptor 2-selective agonist, directly activates neurons associated with respiratory control in the brain and improves respiratory parameters in rodents undergoing fentanyl-induced sedation.
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