Oleic acid-conjugated chitosan (oleyl-chitosan) is a powerful platform for encapsulating oleic acid-decorated iron oxide nanoparticles (ION), resulting in a good magnetic resonance imaging (MRI) probe. Oleyl-chitosan could self-assemble into core-shell structures in aqueous solution and provide the effective core compartment for loading ION. ION-loaded oleyl-chitosan nanoparticles showed good enhanced MRI sensitivity in a MR scanner. Cy5.5 dye was accessed to the oleyl-chitosan conjugate for near-infrared (NIR) in vivo optical imaging. After intravenous injection of ION-loaded Cy5.5-conjugated oleyl-chitosan (ION-Cy5.5-oleyl-chitosan) nanoparticles in tumor-bearing mice, both NIRF and MR imaging showed the detectable signal intensity and enhancement in tumor tissues via enhanced permeability and retention (EPR) effect. Tumor accumulation of the nanoparticles was confirmed through ex vivo fluorescence images and Prussian blue staining images in tumor tissues. It is concluded that ION-Cy5.5-oleyl-chitosan nanoparticle is highly an effective imaging probe for detecting tumor in vivo.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/bc100241a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polymeric nanocarrier-based adjuvants to enhance a locally produced mucosal coryza vaccine in chicken.
Sci Rep
July 2024
Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo, Egypt.
Article Synopsis
- Infectious coryza (IC) is a serious respiratory disease in chickens caused by Avibacterium paragallinarum, leading to higher culling in meat chickens and significant drops in egg production for laying hens.
- The study investigates the use of various nanoparticles (NPs) like silicon dioxide and iron oxide in developing new vaccines and examining their antibacterial effects on the bacteria causing IC.
- Results indicate that a concentration of 400 µg/ml of NPs effectively inactivates A. paragallinarum, with the SiO NP-adjuvanted vaccine generating the strongest immune response compared to other nanoparticle formulations and a commercial vaccine.
Fabrication and characterization of dual acting oleyl chitosan functionalised iron oxide/gold hybrid nanoparticles for MRI and CT imaging.
Int J Biol Macromol
June 2018
Department of Biological Materials, CSIR - Central Leather Research Institute, Adyar, Chennai 600020, India. Electronic address:
Bionanocomposites fabricated using metal nanoparticles serve a wide range of biomedical applications viz., site targeted drug delivery, imaging etc. Theranostics emerge as an important field of science, which focuses on the use of single entity for both disease diagnosis and treatment.
View Article and Find Full Text PDFOleyl-chitosan nanoparticles based on a dual probe for optical/MR imaging in vivo.
Bioconjug Chem
February 2011
Department of Nuclear Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk 561-712, Republic of Korea.
Oleic acid-conjugated chitosan (oleyl-chitosan) is a powerful platform for encapsulating oleic acid-decorated iron oxide nanoparticles (ION), resulting in a good magnetic resonance imaging (MRI) probe. Oleyl-chitosan could self-assemble into core-shell structures in aqueous solution and provide the effective core compartment for loading ION. ION-loaded oleyl-chitosan nanoparticles showed good enhanced MRI sensitivity in a MR scanner.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!