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Severe Post-Viral Polymyositis after COVID-19 in Childhood: A Case Report and Literature Review.
Children (Basel)
August 2024
Department of Pediatrics, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str., 50161 Kaunas, Lithuania.
Polymyositis is a rarely reported complication of COVID-19 illness, especially in children. Molecular mimicry may be a cause of hyperactivated autoimmunity, leading to various clinical manifestations, including myopathies. Symptoms vary from mild muscle weakness to severe rhabdomyolysis.
View Article and Find Full Text PDFPersonalised medicine in juvenile dermatomyositis: From novel insights in disease mechanisms to changes in clinical practice.
Best Pract Res Clin Rheumatol
September 2024
Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:
Juvenile dermatomyositis is characterized by childhood-onset chronic inflammation of the muscles and skin, with potential involvement of other organs. Patients are at risk for long-term morbidity due to insufficient disease control and steroid-related toxicity. Personalised treatment is challenged by a lack of validated tools that can reliably predict treatment response and monitor ongoing (subclinical) inflammation, and by a lack of evidence regarding the best choice of medication for individual patients.
View Article and Find Full Text PDFClinical characteristics and prognostic factor in juvenile dermatomyositis: data of the Spanish registry.
Pediatr Rheumatol Online J
July 2024
Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
Background: Juvenile Dermatomyositis (JDM) is the most common chronic idiopathic inflammatory myopathy in children. The diagnosis is clinical. Baseline laboratory and complementary studies trace the phenotype of these patients.
View Article and Find Full Text PDFCapillaroscopy in the daily clinic of the pediatric rheumatologist.
Best Pract Res Clin Rheumatol
September 2024
Department of Rheumatology, Ghent University Hospital, Belgium; Faculty of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium.
Article Synopsis
- Nailfold capillaroscopy is becoming increasingly important in pediatric rheumatology, aiding in the diagnosis and monitoring of various conditions through a simple, non-invasive procedure.
- The review highlights essential background on capillaroscopy devices, standardized interpretations, and typical variations observed in healthy children versus those with conditions like Raynaud's phenomenon and systemic diseases.
- It also identifies gaps in current research, suggesting a need for further studies on the use of nailfold capillaroscopy in pediatric connective tissue diseases.
Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis.
Sci Rep
July 2024
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Article Synopsis
- Juvenile dermatomyositis (JDM) is a rare childhood autoimmune disease potentially linked to microbial exposure, prompting a study on its association with oral and gut microbiome differences.
- In this study, researchers analyzed microbiome samples from JDM patients and their unaffected family members to understand the impact of genetics and environment on microbiome diversity.
- Findings indicated that JDM patients had microbiomes more similar to their unaffected siblings than to other JDM patients, with specific bacterial differences potentially influencing the disease's development or being a result of immune dysfunction.
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