Objectives: To develop a photographic sun damage assessment scale for forearm skin and test its feasibility and utility for consistent classification of sun damage.

Design: For a blinded comparison, 96 standardized 8 × 10 digital photographs of participants' forearms were taken. Photographs were graded by an expert dermatologist using an existing 9-category dermatologic assessment scoring scale until all categories contained photographs representative of each of 4 clinical signs. Triplicate photographs were provided in identical image sets to 5 community dermatologists for blinded rating using the dermatologic assessment scoring scale.

Setting: Academic skin cancer prevention clinic with high-level experience in assessment of sun-damaged skin.

Participants: Volunteer sample including participants from screenings, chemoprevention, and/or biomarker studies.

Main Outcome Measures: Reproducibility and agreement of grading among dermatologists by Spearman correlation coefficient to assess the correlation of scores given for the same photograph, κ statistics for ordinal data, and variability of scoring among dermatologists, using analysis of variance models with evaluating physician and photographs as main effects and interaction effect variables to account for the difference in scoring among dermatologists.

Results: Correlations (73% to >90%) between dermatologists were all statistically significant (P < .001). Scores showed good to substantial agreement but were significantly different (P < .001) for each of 4 clinical signs and the difference varied significantly (P < .001) among photographs.

Conclusions: With good to substantial agreement, we found the development of a photographic forearm sun damage assessment scale highly feasible. In view of significantly different rating scores, a photographic reference for assessment of sun damage is also necessary.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133014PMC
http://dx.doi.org/10.1001/archdermatol.2010.392DOI Listing

Publication Analysis

Top Keywords

sun damage
16
dermatologic assessment
12
development photographic
8
forearm sun
8
damage assessment
8
assessment scale
8
assessment scoring
8
clinical signs
8
good substantial
8
substantial agreement
8

Similar Publications

Complete chloroplast genome data reveal the existence of the L. complex and its potential introduction pathways into China.

Front Plant Sci

December 2024

Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, China.

, native to North America, is an invasive species in many areas of the world, where it causes serious damage to natural ecosystems and economic losses. However, a dearth of genetic resources and molecular markers has hampered our understanding of its invasion history. Here, we assembled 40 complete chloroplast genomes of species, including 21 individuals, 15 individuals, and four individuals, the sizes of which ranged from 152,412 bp to 153,170 bp.

View Article and Find Full Text PDF

Introduction: The residues of clomazone (Clo) can lead to phytotoxic symptoms such as foliar bleaching, reduced plant height, and decreased maize yields. Herbicide safener represent one of the most economically efficient strategies for mitigating herbicide-induced damage.

Methods: In this study, various seed treatments were implemented, including the immersion of maize seeds in water (CK), immersion in Cyprosulfamide (CSA), soil supplemented with clomazone (ClO) and CSA+ClO, evaluated physiological indicators, chlorophyll content, and qRT-PCR analyses of the maize plants were evaluated under the different treatments.

View Article and Find Full Text PDF

Nanoparticle Vaccine Triggers Interferon-Gamma Production and Confers Protective Immunity against Porcine Reproductive and Respiratory Syndrome Virus.

ACS Nano

January 2025

Key Laboratory of Animal Disease Diagnostics and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

The swine industry annually suffers significant economic losses caused by porcine reproductive and respiratory syndrome virus (PRRSV). Because the available commercial vaccines have limited protective efficacy against epidemic PRRSV, there is an urgent need for innovative solutions. Nanoparticle vaccines induce robust immune responses and have become a promising direction in vaccine development.

View Article and Find Full Text PDF

Cisplatin (CIS) is a broad-spectrum anticancer drug widely used in the clinic; however, one of its side effects is that it can cause intestinal damage such as loss of appetite, vomiting, and diarrhea in patients. Epigallocatechin gallate (EGCG) is one of the main active substances in green tea, which has the effects of antitumor multiple drug resistance, antioxidation, and antiinflammatory properties. The aim of this study was to explore the protective effect of EGCG on CIS-induced intestinal injury in rats.

View Article and Find Full Text PDF

Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma.

Biol Direct

January 2025

Department of Hematology, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, 518172, China.

Background: Multiple myeloma (MM) is a hematological malignancy characterized by uncontrolled proliferation of plasma cells and is currently incurable. Despite advancements in therapeutic strategies, resistance to proteasome inhibitors, particularly bortezomib (BTZ), poses a substantial challenge to disease management. This study aimed to explore the efficacy of boanmycin, a novel antitumor antibiotic, in overcoming resistance to BTZ in MM.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!