AI Article Synopsis
- Nuclei are parts of the brain that help it work properly, and they form during a process called nucleogenesis.
- The study looked at a molecule called Neph2 that helps in the formation of a brain area called the pontine nucleus (PN).
- When Neph2 was reduced or increased, it changed how PN neurons moved and messed up the structure of the pontine nucleus.
Article Abstract
Nuclei are anatomical units of the central nervous system (CNS). Their formation sets the structural basis for the functional organization of the brain, a process known as nucleogenesis. In the present study, we investigated the role of the transmembrane immunoglobulin superfamily molecule Neph2 in the nucleogenesis of the pontine nucleus (PN). Neph2 expression is turned on in migrating PN neurons only after they enter the presumptive nuclear region. Neph2 knockdown disrupted the nuclear organization of PN presumably by changing the migratory behavior of PN neurons inside the nuclear region. Moreover, overexpression of the cytoplasmic region of Neph2, which can sequester intracellular signaling of endogenous Neph2, resulted in similar phenotypes. Overall, these results suggest Neph2 is involved in the nucleogenesis of the PN through the control of neuronal migration inside the nucleus.
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| http://dx.doi.org/10.1016/j.mcn.2011.01.007 | DOI Listing |
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