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Mobile Source Benzene Regulations and Risk of Childhood and Young Adult Hematologic Cancers in Alaska: A Quasi-experimental Study.
Epidemiology
May 2023
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Background: We aimed to evaluate the impact of the EPA's Mobile Source Air Toxics rules (MSAT), which targeted benzene emissions, on childhood and young adult leukemia and lymphoma incidence in Alaska.
Methods: MSAT was implemented in 2011 and produced a dramatic decline in ambient benzene in Alaska. Due to previous benzene-related regulations enacted in the continental United States, MSAT had relatively modest impacts in other states.
Identification of gene expression predictors of occupational benzene exposure.
PLoS One
March 2019
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland, United States of America.
Background: Previously, using microarrays and mRNA-Sequencing (mRNA-Seq) we found that occupational exposure to a range of benzene levels perturbed gene expression in peripheral blood mononuclear cells.
Objectives: In the current study, we sought to identify gene expression biomarkers predictive of benzene exposure below 1 part per million (ppm), the occupational standard in the U.S.
[Hypermethylation and downregulation of tumor suppressor gene p16 in benzene poisoning].
Wei Sheng Yan Jiu
March 2012
National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Objective: To investigate whether benzene negatively affects the expression of p16 through DNA methylation.
Methods: We carried out a case-control study in Chinese occupational benzene poisoning patients. Eleven cases of BP and 8 controls who were matched for age (+/- 5 years), sex, working duration and job title with BP were recruited.
[Cases of benzene-related leukemia reported in periodicals in China and analysis of diagnosis].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
November 2010
Human benzene metabolism following occupational and environmental exposures.
Chem Biol Interact
March 2010
School of Public Health, University of California, Berkeley, CA 94720-7356, USA.
We previously reported evidence that humans metabolize benzene via two enzymes, including a hitherto unrecognized high-affinity enzyme that was responsible for an estimated 73% of total urinary metabolites [sum of phenol (PH), hydroquinone (HQ), catechol (CA), E,E-muconic acid (MA), and S-phenylmercapturic acid (SPMA)] in nonsmoking females exposed to benzene at sub-saturating (ppb) air concentrations. Here, we used the same Michaelis-Menten-like kinetic models to individually analyze urinary levels of PH, HQ, CA and MA from 263 nonsmoking Chinese women (179 benzene-exposed workers and 84 control workers) with estimated benzene air concentrations ranging from less than 0.001-299 ppm.
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