We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent control over the final number and the outgrowth direction of neurites. Taken together, this report provides a novel and promising approach to the rational design of biocompatible textured substrates for tissue engineering applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/nl103349s | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Temporal Tissue Remodeling in Volumetric Muscle Injury with Endothelial Cell-Laden Patterned Nanofibrillar Constructs.
Bioengineering (Basel)
December 2024
Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
A primary challenge following severe musculoskeletal trauma is incomplete muscle regeneration. Current therapies often fail to heal damaged muscle due to dysregulated healing programs and insufficient revascularization early in the repair process. There is a limited understanding of the temporal changes that occur during the early stages of muscle remodeling in response to engineered therapies.
View Article and Find Full Text PDFTitanium Surface Synergy: Strontium Incorporation and Controlled Disorder Nanotopography Optimize Osteoinduction.
ACS Appl Mater Interfaces
November 2024
Centre for the Cellular Microenvironment, School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, The Advanced Research Centre, 11 Chapel Lane, Glasgow G11 6EW, Scotland, U.K.
Osteoporotic fractures and arthritis represent a major socioeconomic health burden. Fragility fracture fixation and joint replacement are often undertaken using titanium (Ti) or Ti alloy implants. Ideally these should induce bone formation and reduce osteoclast formation.
View Article and Find Full Text PDFNanotopography promotes cardiogenesis of pluripotent stem cell-derived embryoid bodies through focal adhesion kinase signaling.
Biochem Biophys Res Commun
November 2024
Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:
Controlling the microenvironment surrounding the pluripotent stem cells (PSCs) is a pivotal strategy for regulating cellular differentiation. Surface nanotopography is one of the key factors influencing the lineage-specific differentiation of PSCs. However, much of the underlying mechanism remains unknown.
View Article and Find Full Text PDFHierarchically structured nanofibrous scaffolds spatiotemporally mediate the osteoimmune micro-environment and promote osteogenesis for periodontitis-related alveolar bone regeneration.
Acta Biomater
November 2024
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address:
Article Synopsis
- Periodontitis leads to inflammation that destroys periodontal tissues and causes significant loss of alveolar bone, necessitating new treatment strategies that focus on inflammation control and bone regeneration.
- Researchers developed a unique nanofibrous scaffold that utilizes a specially designed structure to modulate the osteoimmune environment, demonstrating effectiveness both in lab settings and animal models for reducing inflammation and promoting bone regeneration.
- The findings suggest this innovative scaffold has promising therapeutic potential for treating periodontitis-related bone defects and advancing periodontal tissue regeneration techniques.
Fabrication of anodic and atomic layer deposition-alumina coated titanium implants for effective osteointegration applications.
J Biomed Mater Res A
January 2025
Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey.
Biomimicking the chemical, mechanical, and topographical properties of bone on an implant model is crucial to obtain rapid and effective osteointegration, especially for the large-area fractures of the skeletal system. Titanium-based biomaterials are more frequently preferred in clinical use in such cases and coating these materials with oxide layers having chemical/nanotopographic properties to enhance osteointegration and implantation success rates has been studied for a long time. The objective of this study is to examine the high and rapid mineralization potential of anodized aluminum oxide (AAO) coated and atomic layer deposition (ALD)-alumina coated titanium substrates on large deformation areas with difficult spontaneous healing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!