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Genomic and physiological mechanisms of high-altitude adaptation in Ethiopian highlanders: a comparative perspective.
Front Genet
January 2025
Center of Cellular and Genetic Science, Henan Academy of Sciences, Zhengzhou, China.
High-altitude adaptation is a remarkable example of natural selection, yet the genomic and physiological adaptation mechanisms of Ethiopian highlanders remain poorly understood compared to their Andean and Tibetan counterparts. Ethiopian populations, such as the Amhara and Oromo, exhibit unique adaptive strategies characterized by moderate hemoglobin levels and enhanced arterial oxygen saturation, indicating distinct mechanisms of coping with chronic hypoxia. This review synthesizes current genomic insights into Ethiopian high-altitude adaptation, identifying key candidate genes involved in hypoxia tolerance and examining the influence of genetic diversity and historical admixture on adaptive responses.
View Article and Find Full Text PDFUnveiling the role of BON domain-containing proteins in antibiotic resistance.
Front Microbiol
January 2025
Department of Materials, Loughborough University, Loughborough, United Kingdom.
The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored.
View Article and Find Full Text PDFData-driven discovery of associations between prescribed drugs and dementia risk: A systematic review.
Alzheimers Dement (N Y)
January 2025
Department of Health and Community Sciences, Medical School University of Exeter Exeter UK.
Abstract: Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whether existing medications for other conditions may affect dementia risk. We conducted a systematic review to identify studies adopting a data-driven approach to investigate the association between a wide range of prescribed medications and dementia risk.
View Article and Find Full Text PDFA New Mechanism of Supraventricular Tachycardia: Gene Mutation.
Curr Cardiol Rev
January 2025
Department of Cardiology, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Background: Supraventricular tachycardia (SVT) is very common in daily clinical practice, especially in the emergency department, with rapid onset and urgent management. The review highlights the recent genetic predispositions and mechanisms in SVT.
Methods: Through analysis of epidemiology, familial clustering, and gene mutations of the relevant literatureļ¼the review elucidates the genetic properties and potential pathophysiology of SVT.
Deciphering the Genetic Basis of Sugar Cane ( L) Root System and Related Traits under Nitrogen Stress through the Integration of Genome-Wide Association Studies and RNA-seq.
J Agric Food Chem
January 2025
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi Key Laboratory of Sugarcane Biology, Guangxi University, Nanning 530005, China.
Nitrogen (N) is an essential element for plant growth and development. Identifying functional gene loci associated with nitrogen absorption and utilization in sugar cane can facilitate the development of nutrient-efficient sugar cane varieties. In this study, sugar cane seedlings were subjected to normal and low nitrogen stress treatments within a hydroponic system for the identification of candidate genes related to six root-associated traits using a diversity population of 297 accessions.
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