Fluorescence spectroscopy in cardiovascular disease Fundamental concepts and clinical applications.

Laser-induced fluorescence spectroscopy can distinguish atherosclerotic from normal arteries by their characteristic fluorescence spectra. The ability to perform remote spectroscopy through optical fibers can be incorporated into a "smart" laser angioplasty system. By detecting the presence of atherosclerosis, and by signaling completion of plaque ablation, fluorescence spectroscopy could guide selective laser ablation of atherosclerotic plaques. This guidance capability could result in safe and effective laser angioplasty systems.