AI Article Synopsis
- Analyte quantification in highly scattering biological media is difficult with traditional spectroscopic methods, but ultrasound can penetrate these samples despite offering limited chemical information.
- We developed hydrogel biosensors using antibody-linked cellulose polymers that change stiffness and size upon target recognition, resulting in detectable variations in ultrasonic frequency.
- This approach shows nM sensitivity for acetaminophen in various biofluids and is promising for point-of-care diagnostics due to its quick measurement time and minimal sample preparation requirements.
Article Abstract
Analyte quantification in highly scattering media such as tissue, blood, and other biological fluids is challenging using conventional spectroscopic methods. Ultrasound easily penetrates these opaque samples, yet currently provides little chemical information. We have developed a general approach for creating hydrogel biosensors based on antibody-linked cellulose polymers. Target recognition induces changes to the sensor stiffness and size, which is accompanied by characteristic changes to a measured ultrasonic frequency profile. Using this technique, nM sensitivity for acetaminophen is demonstrated in a series of biofluids including whole blood, blood plasma, saliva, and urine. Likewise, this methodology is attractive for point of care diagnostics due to the short measurement time, simple methodology which excludes pretreatment of samples, and has minimal chemical or buffer requirements.
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| http://dx.doi.org/10.1016/j.talanta.2010.11.010 | DOI Listing |
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