AI Article Synopsis
- A series of ten (±) 3-menthone aryl acid hydrazone compounds were synthesized and characterized using thin layer chromatography and spectral analysis.
- The compounds were tested for anticonvulsant activity in mice through various seizure-inducing methods, with assessments of motor impairment.
- Among the compounds, J(6) was identified as the most effective, showcasing significant anticonvulsant properties and indicating improved safety compared to other menthone derivatives.
Article Abstract
A series of ten compounds (Compounds J(1)-J(10)) of (±) 3-menthone aryl acid hydrazone was synthesized and characterized by thin layer chromatography and spectral analysis. Synthesized compounds were evaluated for anticonvulsant activity after intraperitoneal (i.p) administration to mice by maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure method and minimal clonic seizure test. Minimal motor impairment was also determined for these compounds. Results obtained showed that four compounds out of ten afforded significant protection in the minimal clonic seizure screen at 6 Hz. Compound J(6), 4-Chloro-N-(2-isopropyl-5-methylcyclohexylidene) benzohydrazide was found to be the most active compound with MES ED(50) of 16.1 mg/kg and protective index (pI) of greater than 20, indicating that (±) 3-menthone aryl acid hydrazone possesses better and safer anticonvulsant properties than other reported menthone derivatives viz. menthone Schiff bases, menthone semicarbazides and thiosemicarbazides.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/157340611794072689 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!