Aim: Lisinopril is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. We compared the dissolution profiles of Lisinopril 20 mg tablets (Antibiotice S.A. laşi) and Zestril 20 mg tablets (Astra Zeneca).
Material And Method: Because lisinopril is a third class active substance, we performed dissolution tests in standard media at three pH values: 1.2, 4.5 and 6.8 using the paddle apparatus at 75 rpm.
Results: Both pharmaceutical formulations present a dissolution percentage more than 85% (Q) of the labeled amount.
Conclusion: Both pharmaceutical formulations present similar dissolution profile. Key words:
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