AI Article Synopsis
- The study investigates the effect of peripheral nerve injury on nuclear factor κB activation in spinal ganglia.
- Analysis shows variable expression of specific genes linked to nuclear factor κB after nerve damage and stimulation with TNF-α.
- The findings suggest that nuclear factor κB may play a role in regulating gene transcription in spinal ganglion cells following trauma.
Article Abstract
The aim of this study was to clear out whether injury to the peripheral nerve leads to activation of nuclear factor κB in mature spinal ganglia. Analysis of matrix RNA of nuclear factor κB-dependent genes (monocyte chemoattractant protein MCP-1 and inhibitor of nuclear factor κB IκBα) showed different levels of expression of these genes in the spinal ganglia in vivo after axotomy and in vitro after TNF-α stimulation. On the other hand, DNA-binding activity of nuclear factor κB increased in the spinal ganglia 6 h after axotomy and after 10-min incubation of sensory neuron culture with TNF-α. These data attest to possible involvement of nuclear factor κB in the posttraumatic regulation of gene transcription in spinal ganglion cells.
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| http://dx.doi.org/10.1007/s10517-010-0974-4 | DOI Listing |
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