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Growth Hormone, Insulin-Like Growth Factor-1, Insulin Resistance, and Leukocyte Telomere Length as Determinants of Arterial Aging in Subjects Free of Cardiovascular Diseases.
Front Genet
December 2017
National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Increased arterial stiffness (AS), intima-media thickness (IMT), and the presence of atherosclerotic plaques (PP) have been considered as important aspects of vascular aging. It is well documented that the cardiovascular system is an important target organ for growth hormone (GH) and insulin-like growth factor (IGF)-1 in humans, and GH /IGF-1 deficiency significantly increases the risk for cardiovascular diseases (CVD). The telomere length of peripheral blood leukocytes (LTL) is a biomarker of cellular senescence and that has been proposed as an independent predictor of (CVD).
View Article and Find Full Text PDF[The genetic aspects of occupational hearing impairment].
Vestn Otorinolaringol
March 2018
Krasnoyarsk Research Centre of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia, 660036.
This article was designed to be the overview of the current literature publications concerning the identification of the genetic markers of susceptibility to the noise-induced loss of hearing. The analysis of these data has demonstrated that the major gene polymorphisms associated with the development of this pathological condition are localized in the genes encoding for the antioxidant systems, potassium homeostasis, and adhesion molecules as well as in the genes involved in intercellular coupling, the mechanisms underlying the cellular response to stress, activation and regulation of heat shock proteins, and signaling function of the immune system. It is concluded that the further investigations into the genetic aspects of the full-genome sequencing techniques and the search for genomic associations could greatly contribute to the development of personalized medicine and the reduction of risks of occupational noise-induced sensorineural impairment of hearing.
View Article and Find Full Text PDF[The prospects for the further development of the Belokurikha spa and health resort territory in the Altai Krai (region)].
Vopr Kurortol Fizioter Lech Fiz Kult
July 2016
Joint-stock company 'Belokurikha spa and health resort', Belokurikha, Altai Krai, Russia.
We undertook a balneological survey of the Belokurikha spa and health resort territory with the purpose of distinguishing and identifying the potential health-improvement areas most promising for the extension and optimization of the therapeutic, tourist and recreational activities. The assessment was focused on the characteristic of the landscape and climatic conditions of the territory, the possibilities for the development of the existing resources of mineral waters and therapeutic muds as well as for the discovery of the potential new ones. The recommendations are proposed to promote the development of different forms of tourism with special reference to its medical and health-improvement aspects.
View Article and Find Full Text PDF[Problems concerning diseases of internal organs (medico-biological aspect)].
Klin Med (Mosk)
March 2015
This review considers the views of I.V. Davydovsky expounded in his book The Problems of Causality in Medicine.
View Article and Find Full Text PDFIn the overview one can find analysis medico-biological aspects of free radical theory, clinical experience of antioxidants using, perspectives of new active agents and possible directions of theirs practical use.
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