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Preoperative [F]fluoro-PEG-folate PET/CT in advanced stage epithelial ovarian cancer: A safety and feasibility study.
Nucl Med Biol
December 2024
Department of Gynecology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:
Article Synopsis
- The study investigates the use of folate receptor (FR)-targeted PET/CT imaging with [F]fluoro-PEG-folate for better preoperative assessment in advanced-stage epithelial ovarian cancer (EOC), aiming to enhance selection for cytoreductive surgery (CRS) and reduce unnecessary procedures.
- It evaluates the safety and tolerability of [F]fluoro-PEG-folate through vital sign monitoring and adverse event recording, along with quantifying disease burden using the Peritoneal Cancer Index (PCI) score from imaging and surgical findings.
- The study was halted early after including eight patients, revealing that while [F]fluoro-PEG-folate was safe
Challenges in Pharmacokinetic Modelling of [F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients.
Mol Imaging Biol
August 2024
Dept. of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Purpose: To describe the pharmacokinetic properties of the [F]fluoro-polyethylene glycol(PEG)-folate radiotracer in PET/CT imaging of patients with advanced stage epithelial ovarian cancer (EOC).
Procedures: In five patients with advanced EOC (FIGO stage IIIB/IIIC, Fédération Internationale de Gynécologie et d'Obstétrique), a 90-min dynamic PET acquisition of the pelvis was performed directly after i.v.
Emerging organic compounds as markers of the degradation of groundwater qualitative and quantitative equilibrium in a context of rapid urban expansion.
Sci Total Environ
March 2024
Université de Corse Pascal Paoli, Département d'Hydrogéologie, Campus Grimaldi, BP52, 20250 Corte, France; CNRS, UMR 6134 SPE, BP52, 20250 Corte, France.
With the neo-metamorphosis of the residential landscape worldwide and sluggish sanitation strategies in urban environments, rudimentary on-site sanitation systems remain commonly used, especially in developing countries, despite the risks of groundwater contamination. The effective management of such water resources relies on assessment of the sensitivity of anthropized aquifers to man-made impact, including groundwater behavioural alteration, in terms of both quality and quantity. Associated with tracking of changes in land use, this study proposes an approach involving emerging organic contaminants (EOCs) as indicators of the alteration of groundwater balance due the exposure of shallow aquifers to the risks of infiltration of untreated wastewater from soak pits.
View Article and Find Full Text PDF[Ga]Ga-FAPI-04 PET/CT in the evaluation of epithelial ovarian cancer: comparison with [F]F-FDG PET/CT.
Eur J Nucl Med Mol Imaging
November 2023
Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuhan, 430071, China.
Purpose: To compare the efficacy of [Ga]Ga-FAPI-04 PET/CT in primary or recurrent tumors and metastatic lesions of epithelial ovarian cancer (EOC) with that of fluorine-18 fluorodeoxyglucose ([F]F-FDG) PET/CT.
Methods: Forty-nine patients (median age, 57 years; IQR, 51-66 years) with histologically proven primary or relapsed EOC were enrolled. Participants underwent [F]F-FDG and [Ga]Ga-FAPI-04 PET/CT.
Emerging organic contaminants in the River Ganga and key tributaries in the middle Gangetic Plain, India: Characterization, distribution & controls.
Environ Pollut
June 2023
British Geological Survey, Maclean Building, Wallingford, Oxfordshire, OX10 8BB, UK.
The presence and distribution of emerging organic contaminants (EOCs) in freshwater environments is a key issue in India and globally, particularly due to ecotoxicological and potential antimicrobial resistance concerns. Here we have investigated the composition and spatial distribution of EOCs in surface water along a ∼500 km segment of the iconic River Ganges (Ganga) and key tributaries in the middle Gangetic Plain of Northern India. Using a broad screening approach, in 11 surface water samples, we identified 51 EOCs, comprising of pharmaceuticals, agrochemicals, lifestyle and industrial chemicals.
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