AI Article Synopsis

  • A 61-year-old woman with sigmoid colon cancer and unresectable lung and liver metastases initially underwent standard chemotherapy (bevacizumab plus mFOLFOX6) but experienced only a temporary partial response.
  • After multiple unsuccessful treatments, including second and third-line therapies, her condition worsened due to liver metastases causing cholangitis and anemia.
  • The final treatment involved hepatic arterial infusion chemotherapy for liver metastases and cetuximab for lung metastases, leading to significant improvements in both serum CEA levels and her overall health status over a three-month period.

Article Abstract

We report a case of multiple lung and liver metastases from colon cancer treated with clinical benefit by hepatic arterial infusion chemotherapy plus cetuximab mono-therapy after a standard chemotherapy was failed. A 61-year-old female who had sigmoid colon cancer with unresectable multiple lung and liver metastases underwent sigmoidectomy. Bevacizumab plus mFOLFOX6 was performed as first-line therapy. Partial response was obtained temporarily. After the first-line therapy failed, bevacizumab plus FOLFIRI as second-line, and cetuximab plus CPT-11 as third-line therapy were performed. Since these regimens did not work, her performance status got worse by cholangitis due to progressive liver metastases and anemia. Hepatic arterial infusion chemotherapy for liver metastases and cetuximab for lung metastases as fourth therapy were chosen because we thought her liver metastases should be critical for the maintenance of her QOL and diagnosis. After that, serum CEA was reduced from 14,715 to 6,940 ng/mL during the 3 month period. And her performance status got better as cholongitis and anemia were improved. Additionally, lung metastases were controlled by cetuximab.

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