Objective: To evaluate the rare entity of partial mole or choriocarcinoma with co-existing fetus.
Methods: A total of 7 cases of partial mole or choriocarcinoma with co-existing fetus were selected to collect clinical profiles and perform auxiliary examinations such as serum β-hCG and sonography. The data were analyzed retrospectively and all cases confirmed by surgery and histopathological diagnosis.
Results: There were 5 cases of partial moles with co-existing fetus. All patients stayed alive at follow-up. However, only 1 fetus delivered at 32-week gestation survived. All patients of choriocarcinoma with co-existing fetus died. Among them, 1 newborn died and another one lost follow-up after 2 years.
Conclusion: Recently the rate of gestational trophoblastic disease with co-existing fetus is rising. It is quite important that the professionals of genetics, reproductive medicine, gynecological oncology, perinatal medicine and pathology should pay more attention to this emerging disease.
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