[Effect of endometrial stimulation on pregnancy outcome of in vitro fertilization patients].

Objective: To analyze the effect of endometrial stimulation on the pregnancy outcome of patients undergoing in vitro fertilization-embryo transfer (IVF-ET).

Methods: A total of 759 subjects were treated by fresh IVF at our hospital in 2007. Sixty-eight subjects received endometrial stimulation at Days 4-5 of menstruation before IVF while other 691 were controls without treatment. No significant difference was found between two groups in terms of duration and cause for infertility, day and dosage of Gn, number of retrieved oocytes and transferred embryos and fertilization rate. The clinical pregnancy rate of two groups were analyzed. Firstly the clinical outcomes for the patients of primary or secondary infertility were compared in treatment and control groups respectively. Then the clinical outcomes of the patients in first cycle and later cycles were compared in treatment and control groups respectively.

Results: There were no significant differences in clinical pregnancy rate and incidence of abortion and ectopic pregnancy. For first cyclers, the clinical pregnancy rate showed no significant difference between two groups (38.89% vs 37.16%). But for later cyclers, the clinical pregnancy rate was higher in the treatment group than that in the control group (53.13% vs 34.33%).

Conclusion: Endometrial stimulation may improve endometrial receptivity to some extent. And it can boost the clinical pregnancy rate for those patients with a repeated implantation failure.