[Diagnosis and treatment of atypical adenomatous pulmonary hyperplasia in lungs].

Objective: To analyze the characteristic of atypical adenomatous hyperplasia (AAH) in lungs though its computerized tomography (CT) scan, pathology and surgical mode.

Methods: The investigators retrospectively evaluated 10 atypical adenomatous hyperplasias (AAH) that were histologically confirmed and that manifested pure ground glass opacity (GGO) on thin-section helical CT scans. There were 2 males and 8 females with a median age 54.4 years old. All patients had the surgery. Their characteristic of CT scan and pathology were compared. All received a follow-up.

Results: In all cases, peripheral nodules were located at left upper lobe (n = 4), left lower lobe (n = 2) and right lower lobe (n = 4). GGO at a diameter of 0.5 - 1.2 cm was manifested on thin-section helical CT scans. The borderline of GGO was distinct and there was an equal density. Two of 10 cases underwent a wedge resection and 8 lobectomy. Postoperative patients recovered quickly without severe complications. Microscopically it manifested an apparent local pattern of alveolus epithelium hyperplasia in lungs. The alveolar interval had a slight increase. Local hyperplasia of fibrous cells was present with a slight degree of nucleus heteromorphism. The follow-up period was 2 months to 5 years. Ten patients with an excellent life quality survive without recurrence and metastasis.

Conclusion: The preoperative diagnostic rate of AAH is boosted by high-differentiation enhancement CT scan and CT number histograms. But a definite diagnosis still requires the histological evidence. Surgery is one of the most reliable therapy for AAH.