The object of this study is to describe the behaviour of heroin users from an economic point of view in such a way as to enable tracing the influence of policy measures. In order to describe the heroin users' behaviour, data have been collected regarding relevant variables and relations between variables by interviewing 80 heroin users in the Netherlands. Based on these data a computer model has been developed. The objective of the model is two-fold: 1) Describing the behaviour of a group of heroin users in connection with the process of obtaining money and heroin in order to determine the factors which influence the quantity of heroin bought and consumed. 2) Carrying out some scenario analyses in order to examine the effects policy changes might have on variables such as heroin use and quantity of money obtained illegally.
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J Voice
January 2025
Department of Audio, Video, and Electronic Forensics, Academy of Forensic Science, Shanghai, China; Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai, China.
Drug abuse can cause severe damage to the human speech organs. The vocal folds are one of the important speech organs that produce voice through vibration when airflow passes through. Previous studies have reported the negative effects of drugs on speech organs, including the vocal folds, but there is still limited research on relevant field.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
In Canada, the ongoing fatal overdose crisis remains driven by the unpredictable potency and content of the illicit drug supply. From August 2022 until October 2023, the Drug User Liberation Front [DULF] operated a drug compassion club [CC], which sells drugs of known composition and purity without medical oversight. The present study is a qualitative evaluation of this project.
View Article and Find Full Text PDFBiol Psychiatry
December 2024
Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Addiction Institute of Mount Sinai, New York, New York, USA. Electronic address:
Background: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior mediated by the orbitofrontal cortex (OFC), and next-generation sequencing could provide insights regarding novel targets.
Methods: Here, we used machine learning to evaluate human post-mortem OFC RNA-sequencing datasets from heroin-users and controls to identify transcripts predictive of heroin use.
Subst Use Misuse
December 2024
Centre d'étude des mouvements sociaux (Inserm U1276, /UMR CNRS 8044, /EHESS/Paris), Paris, France.
Background: Opioid Use Disorder (OUD) often provokes dramatic consequences in terms of increased morbi-mortality. Two medications have mainly been worldwide used for OUD (MOUD), buprenorphine and methadone. Recently, however, some reports have highlighted the use of Morphine Sulfate (MS) mainly obtained without a prescription but used as MOUD by opioid users and especially People Who Inject Substances (PWIS).
View Article and Find Full Text PDFIndian J Psychol Med
April 2024
Indian Drug Users Forum, New Delhi, India.
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