Objective: The nocturnal blood pressure (NBP) reduction is less than normal in the patients with type 2 diabetes mellitus (type 2 DM). L-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM. The purpose of the study was to investigate whether there is a difference in levels of L-carnitine in dipper and nondippers patients with type 2 DM.
Methods: This is a cross-sectional observational cohort study. We compared the 50 (33 females, 17 males) patients with type 2 DM and the 35 healthy persons (18 females, 17 males) as a control group. In all cases, ambulatory blood pressure monitoring (ABPM) was performed and L-carnitine was measured. The independent samples t test, Chi-square test, Mann-Whitney U test and Pearson correlation analysis were used in the statistical evaluation of data.
Results: We found that the percentage of nondipper pattern was 72% in patients with type 2 DM. L-carnitine levels were lower in patients with type 2 DM (52.77 ± 12.34 µmol/L) than those of control group (79.18 ± 10.59 µmol/L), and these differences were statistically significant (p=0.05). L-carnitine levels were lower in nondipper cases (50.02 ± 16.30 µmol/L) than those of dipper cases (53.83 ± 10.50 µmol/L), but these differences were not statistically significant (p=0.125).
Conclusion: Nondipper pattern is common in patients with type 2 DM. Nondipper pattern is associated with damage of target organ. Therefore, determination of nondipper pattern by ABPM is very important. L-carnitine levels were found to be lower in nondipper patients than in dipper patients with type 2 DM. Although, these differences were statistically nonsignificant, more detailed studies should be performed to determine the frequencies and relationship between nondipper pattern and L-carnitine levels in patients with type-2 DM.
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http://dx.doi.org/10.5152/akd.2011.008 | DOI Listing |
Traffic Inj Prev
January 2025
Soen Driving School, Hokkaido, Japan.
Objectives: This study aimed to validate the hazard perception task developed for Japanese drivers with brain damage.
Methods: A total of 36 professional driving instructors, 67 older adult drivers, 39 young drivers, and 72 patients with brain damage participated in the study. A video-based hazard perception task measured the hazard perception skills of each group.
Sao Paulo Med J
January 2025
Professor, Master's Program in Innovation in Higher Education in Health, Universidade Municipal de São Caetano do Sul (USCS), São Caetano do Sul (SP), Brazil.
Background: Although multiple strategies have been suggested for evidence-based practice educational interventions, few studies have focused on the development of abilities for evidence-based practice implementation.
Objective: To explore the effectiveness of evidence-based practice in higher education and understand its teaching methods.
Design And Setting: Narrative review was conducted at the Universidade Municipal de São Caetano do Sul, Brazil.
Codas
January 2025
Instituto de Psicologia, Serviço Social, Saúde e Comunicação Humana, Universidade Federal do Rio Grande do Sul - UFRGS - Porto Alegre (RS), Brasil.
Purpose: To ascertain whether Rapid Maxillary Expansion (RME) elicits effects on the functioning of the middle ear and air-bone gaps in children and adolescents.
Methods: Single-arm clinical trial, with data collection at four time points: before initiating Rapid Maxillary Expansion (RME) (T0), upon completion of RME (T1), three months post-RME completion (T2), and six months post-RME procedure (T3). The audiological assessment, conducted at all four time points, comprised otoscopy, pure tone and speech audiometry, tympanometry, and acoustic reflex investigation.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: To assess the sensitivity and specificity of the retinopathy of prematurity score (ROPScore) and weight, insulin-like growth factor-1, retinopathy of prematurity algorithm in predicting the risk of developing severe retinopathy of prematurity (prethreshold type 1) in a sample of preterm infants in Brazil.
Methods: Retrospective analysis of medical records of preterm infants (n=288) with birth weight of ≤1500 g and/or gestational age of 23-32 weeks in a neonatal unit in Southern Brazil from May 2013 to December 2020 (92 months).
Results: The incidence of confirmed severe retinopathy of prematurity was 6.
J Trauma Nurs
January 2025
Author Affiliations: St Andrew's Anglia Ruskin (StAAR) Research Group, Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford, UK (Dr Adegboye); Division of Plastic and Reconstructive Surgery, Red Cross War Memorial Children's Hospital; and Division of Plastic & Reconstructive Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa (Dr Pillay and Prof Adams).
Background: Contemporary research has shown that acellular dermal matrices can benefit adult lower extremity traumatic injuries; however, its use in children has not been explored.
Objective: This study aims to explore the use of acellular dermal matrices in pediatric complex lower extremity trauma.
Methods: This single-center retrospective observational cohort study of children with complex lower extremity trauma treated with Pelnac™, commercial acellular dermal matrices, was conducted at a tertiary hospital in South Africa from 2010 to 2017.
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