Machine learning-based prediction has been effectively applied for many healthcare applications. Predicting breast screening attendance using machine learning (prior to the actual mammogram) is a new field. This paper presents new predictor attributes for such an algorithm. It describes a new hybrid algorithm that relies on back-propagation and radial basis function-based neural networks for prediction. The algorithm has been developed in an open source-based environment. The algorithm was tested on a 13-year dataset (1995-2008). This paper compares the algorithm and validates its accuracy and efficiency with different platforms. Nearly 80% accuracy and 88% positive predictive value and sensitivity were recorded for the algorithm. The results were encouraging; 40-50% of negative predictive value and specificity warrant further work. Preliminary results were promising and provided ample amount of reasons for testing the algorithm on a larger scale.
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http://dx.doi.org/10.1109/TITB.2010.2103954 | DOI Listing |
J Med Imaging (Bellingham)
January 2025
The University of Tokyo Hospital, Department of Radiology, Tokyo, Japan.
Purpose: The prevalence of type 2 diabetes mellitus (T2DM) has been steadily increasing over the years. We aim to predict the occurrence of T2DM using mammography images within 5 years using two different methods and compare their performance.
Approach: We examined 312 samples, including 110 positive cases (developed T2DM after 5 years) and 202 negative cases (did not develop T2DM) using two different methods.
Breast Cancer Res Treat
January 2025
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, 34390, Faith, Istanbul, Turkey.
Purpose: This study aimed to determine estrogen receptor (ER) expression in stromal cells in postchemotherapy tumor bed (PCTB) and its relationship with tumor regression and tumor characteristics.
Methods: The study included 490 breast cancer patients who received neoadjuvant chemotherapy (NAC). We performed ER in stromal cells in all resection specimens and available pre-treatment core biopsy materials of 299 patients immunohistochemically.
Histopathology
January 2025
Division of Molecular Medicine, Leeds Institute of Medical Research, St James's University Hospital, University of Leeds, Leeds, UK.
Aims: Threonine and tyrosine kinase (TTK) is up-regulated in triple-negative breast cancer (TNBC), yet its expression in patients undergoing neoadjuvant chemotherapy (NACT) remains unexplored. This investigation aims to assess TTK protein expression in treatment-naïve pre-treatment cores and paired pre- and post-NACT breast cancer (BC) cohorts, as well as its correlation with microcephaly 1 (MCPH1) protein expression.
Methods And Results: Transcriptomic data were sourced from the Gene Expression Omnibus microarray database for mRNA expression analysis.
PLoS One
January 2025
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
A Directed Acyclic Graph (DAG) offers an easy approach to define causal structures among gathered nodes: causal linkages are represented by arrows between the variables, leading from cause to effect. Recently, industry and academics have paid close attention to DAG structure learning from observable data, and many techniques have been put out to address the problem. We provide a two-step approach, named SEMdag(), that can be used to quickly learn high-dimensional linear SEMs.
View Article and Find Full Text PDFNat Med
January 2025
Institute for Social Medicine and Epidemiology, University of Lübeck, Lubeck, Germany.
Artificial intelligence (AI) in mammography screening has shown promise in retrospective evaluations, but few prospective studies exist. PRAIM is an observational, multicenter, real-world, noninferiority, implementation study comparing the performance of AI-supported double reading to standard double reading (without AI) among women (50-69 years old) undergoing organized mammography screening at 12 sites in Germany. Radiologists in this study voluntarily chose whether to use the AI system.
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