AI Article Synopsis
- The study aimed to analyze how a mumps cataplasm releases compounds and penetrates the skin in a lab setting.
- Researchers employed a method called Franz diffusion to measure drug concentration, using HPLC for DCS and UV for flavonoids.
- Results showed that the skin absorption of DCS and flavonoids was 32% and 21%, respectively, while their release percentages were 47% and 42%, indicating a zero-order kinetics process in line with the Higuchi equation.
Article Abstract
Objective: To investigate the in vitro release and transdermal behaviors of mumps cataplasm of complex prescription.
Methods: The improved Franz difficusion was used and the concentration of drugs was detected. DCS was determined by HPLC and flavanoid contents were determined by UV.
Results: The accumulation skin permeation percentage of DCS and flavanoid was 32% and 21%, respectively, the in vitro release percentage of DCS and flavanoid was 47% and 42%, respectively.
Conclusion: The transdermal behavior of mumps cataplasm of complex prescription is an zero-order kinetics progress. The in vitro release behavior is in accordance with the Higuchi equation.
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