The constant increase in number vf patients with AIDS contributed to an increased interest for the mechanisms by which the human immunodeficiency virus provoked disorders of the immune system and disturbed functions of infected tissues and organs. The complex structure, tropism for some cell populations, specific life cycle and multiple interactions with host defence-system make the human immunodeficiency virus one of the most challenging pathogenic agents in medicine. The article deals with data from literature on some known facts as well as with assumptions which partially elucidate the pathogenesis of infection with human immunodeficiency virus.

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