Stevioside, an ent-kaurene type of diterpenoid glycoside, is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni. Stevioside and a few related compounds are regarded as the most common active principles of the plant. Such phytochemicals have not only been established as non-caloric sweeteners, but reported to exhibit some other pharmacological activities also. In this article, natural distribution of stevioside and related compounds, their structural features, plausible biosynthetic pathways along with an insight into the structure-sweetness relationship are presented. Besides, the pharmacokinetics, wide-range of pharmacological potentials, safety evaluation and clinical trials of these ent-kaurene glycosides are revisited.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ardp.201000181 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
LED light improves shoot multiplication, steviol glycosides and phenolic compounds biosynthesis in Stevia rebaudiana Bertoni in vitro culture.
Sci Rep
December 2024
The Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Niezapominajek 21, 30-239, Kraków, Poland.
Light-emitting diode (LED) lamps are efficient elicitors of secondary metabolites. To investigate the influence of LED light on steviol glycosides (SGs) and phenolic compounds biosynthesis, stevia shoots were cultured under the following LED lights: white-WL, blue-B, red-R, 70% red and 30% blue-RB, 50% UV, 35% red and 15% blue-RBUV, 50% green, 35% red and 15% blue-RBG, 50% yellow, 35% red and 15% blue-RBY, 50% far-red, 35% red and 15% blue-RBFR and white fluorescent light (WFl, control). RBG light stimulated shoots' biomass production.
View Article and Find Full Text PDFEffect of Ethyl Acetate on the Defatting of Leaves in the Extraction of Bertoni.
Food Technol Biotechnol
September 2024
Central Laboratory, School of Exact, Chemical and Life Sciences, Misiones National University, Félix de Azara 1552, 3300-Posadas, Argentina.
Research Background: The process for producing purified steviol glycosides from leaves (stevia) generally involves pretreatments, extraction, purification and crystallization. Pre-extraction or defatting can sometimes be a part of this process. It can remove impurities of low polarity, such as chlorophyll and fatty compounds.
View Article and Find Full Text PDFComparison between bacterial bio-formulations and gibberellic acid effects on Stevia rebaudiana growth and production of steviol glycosides through regulating their encoding genes.
Sci Rep
October 2024
Botany Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Stevia rebaudiana is associated with the production of calorie-free steviol glycosides (SGs) sweetener, receiving worldwide interest as a sugar substitute for people with metabolic disorders. The aim of this investigation is to show the promising role of endophytic bacterial strains isolated from Stevia rebaudiana Egy1 leaves as a biofertilizer integrated with Azospirillum brasilense ATCC 29,145 and gibberellic acid (GA) to improve another variety of stevia (S. rebaudiana Shou-2) growth, bioactive compound production, expression of SGs involved genes, and stevioside content.
View Article and Find Full Text PDFEffects of dietary stevia extract supplementation on growth performance, serum biochemical indices, and intestinal health of yellow-feathered broilers.
J Anim Sci
January 2024
College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Stevia, a perennial shrub from the genus Stevia in the Asteraceae family, contains active ingredients like chlorogenic acid and shows promise as a natural feed additive. Despite this potential, there is limited research on the impact of stevia extract specifically on yellow-feather broilers. The study aimed to evaluate the effects of dietary stevia extract with varying concentrations of chlorogenic acid on the growth performance, serum biochemical indices, and intestinal health of yellow-feathered broilers.
View Article and Find Full Text PDFExploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients.
Front Pharmacol
August 2024
Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan.
Article Synopsis
- Diabetes is a major global health issue linked to high blood sugar, with synthetic sugar substitutes facing bans due to harmful side effects like cancer and toxicity.
- The study focuses on the safety and effectiveness of Stevioside, a natural sweetener, by examining its interaction and binding affinity with proteins related to diabetes, using advanced molecular docking techniques.
- Findings indicate that Stevioside shows strong binding to key proteins (GLUT-4, Akt, IR, IRS-1) with no adverse effects or toxicities, suggesting it could be a safe and potent alternative for managing diabetes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!