AI Article Synopsis
- Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder following Alzheimer's disease, but its underlying mechanisms remain largely unclear.
- Factors like abnormal protein folding, oxidative stress, and neuroinflammation have been linked to neurodegenerative diseases and may trigger the progression of these conditions.
- The review will emphasize the roles of heat shock proteins HSP70 and HSP90 in PD, discussing how they may help prevent protein misfolding and reduce cell death in the context of the disease.
Article Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Despite a large amount of research, the pathogenetic mechanism of these diseases has not yet been clarified. Abnormal protein folding, oxidative stress, mitochondrial dysfunction, and apoptotic mechanisms have all been reported as causes of neurodegenerative diseases in association with neuroinflammatory mechanisms which, by generating deleterious molecules, could promote the cascade of events leading to neurodegeneration. Heat shock proteins (HSPs) play a central role in preventing protein misfolding and inhibiting apoptotic activity, and represent a class of proteins potentially involved in PD pathogenesis. The present review will focus on two HSPs, HSP70 and HSP90, with the aim of specifying their role in PD pathogenesis.
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| http://dx.doi.org/10.1159/000321548 | DOI Listing |
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