AI Article Synopsis
- Genotyping studies reveal that Trypanosoma cruzi lineages exhibit a distinct geographic distribution in Latin America, with varying dominance in different regions.
- A new immunological method using Western blot (TSSA-WB) was developed to assess the distribution of T. cruzi lineages through their specific antigens, demonstrating good agreement with traditional genotyping tests.
- Unexpectedly, TSSA II was frequently recognized in northern regions like Colombia, Venezuela, and Mexico, indicating an emerging presence of the TCII lineage where TC I was previously thought to be the only infecting lineage.
Article Abstract
Genotyping studies show a polarized geographic distribution of Trypanosoma cruzi lineages in humans. Here, we assessed their distribution along Latin America through an immunological approach we designated Western blot (WB) assay with Trypomastigote small-surface antigen (TSSA) I and TSSA II (TSSA-WB). These antigens are expressed by T. cruzi I (TCI; now TcI) and T. cruzi II (TCII; reclassified as TcII to TcVI) parasites. TSSA-WB showed good concordance with genotyping tests. An unexpected frequency of TSSA II recognition was observed in Colombia, Venezuela, and Mexico (northern region of Latin America). In Argentina and Paraguay (southern region), immunophenotyping confirmed the already reported TCII (TcII to TcVI) dominance. The lineage distribution between these regions showed significant difference but not among countries within them (except for Colombia and Venezuela). TSSA-WB shows TCII emergence in the northern region where TCI was reported as dominant or even as the unique T. cruzi lineage infecting humans.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005503 | PMC |
| http://dx.doi.org/10.4269/ajtmh.2011.10-0177 | DOI Listing |
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