Purpose: The major drawbacks of brain computed tomography (CT) perfusion are limited coverage in the z-axis, radiation exposure and the use of contrast medium, all of which increase when CT angiography (CTA) is performed with double acquisitions. The purpose of this study was to investigate the feasibility of the 'toggling-table' technique using a 40-mm detector.
Materials And Methods: The clinical usefulness of CT perfusion and 4D-CTA (time-resolved 3D-CTA), as well as the time taken and radiation exposure, were assessed in 14 non-ischemic patients clinically indicated for CT perfusion and CTA.
Results: A perfusion map and 4D-CTA was successfully achieved in all patients. The total time needed for scanning and processing was approximately 30 min per examination. The 80-mm CT perfusion coverage and 4D-CTA images were advantageous for analyses of the anatomy and widely distributed lesions. The estimated effective radiation dose was 2.22 mSv, and the amount of contrast media was 40 mL.
Conclusion: The 'toggling-table' technique acts as a 'one-stop-shop' protocol for perfusion mapping and 4D-CTA over a wide area, following a single contrast injection and scan.
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http://dx.doi.org/10.1016/j.neurad.2010.10.004 | DOI Listing |
Int J Cell Biol
January 2025
Department of Biotechnology and Plant Breeding, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran.
Radiation therapy is one of the most effective treatments for approximately 60% of patients with cancer. During radiation exposure, the overproduction of reactive oxygen species (ROS) disrupts the lipid layer of the membrane, leading to subsequent peroxide radical formation. Cimetidine (Cim) and famotidine (Fam) are histamine H2 receptor antagonists (H2 blocker), also known as peptic ulcer drugs, that exert radioprotective effects.
View Article and Find Full Text PDFCureus
December 2024
Department of Basic and Clinical Oral Sciences, Umm Al-Qura University, Makkah, SAU.
Objectives: Head and neck malignancies (HNMs) encompass a variety of cancers that affect the oral and para-oral tissues, the most common of which are squamous cell carcinomas. Radiotherapy is commonly used to treat these cancers, often involving radiation exposure to the salivary glands. This study aims to investigate the early impacts of radiotherapy on the internal microstructure of the salivary gland cells and identify which gland exhibits the highest level of radiosensitivity.
View Article and Find Full Text PDFNanoscale Adv
January 2025
Grupo de Física Nuclear, EMFTEL & IPARCOS, Universidad Complutense de Madrid Pl. de las Ciencias, 1, Moncloa-Aravaca Madrid Spain
Radiation therapy is a common cancer treatment but often damages surrounding healthy tissues, leading to unwanted side effects. Despite technological advancements aimed at improving targeting, minimizing exposure to normal cells remains a major challenge. High-Z nanoparticles, such as gold nanoparticles (AuNPs), are being explored as nano-radiosensitizers to enhance cancer treatment through physical, biological, and chemical mechanisms.
View Article and Find Full Text PDFJACC CardioOncol
December 2024
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
J Cardiovasc Pharmacol Ther
January 2025
Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.
Background: Neurohormonal blocking drugs, like beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers (ARBs), are recommended for treating anthracycline-induced left ventricular dysfunction (AILVD). However, there is limited evidence supporting their benefit. Therefore, this study evaluated associations of neurohormonal blockers and other clinical factors with recovery of left ventricular ejection fraction (LVEF) in patients with AILVD.
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