AI Article Synopsis
- The study aimed to explore the differences in serum proteins between monozygotic twins with different esotropia (eye misalignment) conditions and non-strabismic children.
- Using advanced SELDI-TOF-MS technology, researchers identified specific proteins in twins, ultimately validating their findings in a larger group of esotropic and orthotropic children.
- Results indicated four significant protein peaks, with three down-regulated and one up-regulated in strabismus patients, suggesting that proteins like glucagons precursor and PACAP may be linked to congenital esotropia.
Article Abstract
Objective: To investigate the serum differentially expressed proteins in discordance of congenital esotropia phenotypes in monozygotic twins and non-strabismus ones.
Methods: SELDI-TOF-MS technology was used to detect the changes of protein expression in a couple of twins with phenotype discordance esotropia (twins A is orthotropia and twins B is esotropia). In addition, two non-twins esotropia and 2 orthotropia children with the same age were chosen. The obtained serum differential expression proteome was validated in 12 non-twins esotropia and 18 orthotropia children and initial predication by proteinum database.
Results: The result of SELDI-TOF-MS in 6 serums showed that four differential expression protein peaks, the molecular weight of these different proteins were 4146, 4801, 7786 and 5859, and the former 3 proteins were down-regulated and last one was up-regulated. Their features were fairly coincident with glucagons precursor, pituitary adenylate cyclase activating peptide (PACAP), cAMP dependent protein kinase inhibitor α and anti-metastasis gene (antigen).
Conclusions: The expression of different proteins among the esotropic and orthotopic children was existed. The expression of different proteins was main down-regulated in the strabismus patients. Glucagons precursor, protein kinase A inhibitor α and PACAP may be related with occurrence of congenital esotropia.
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