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Upping the ante (with machine-learning) for patients with UTUC.
Can Urol Assoc J
December 2024
Division of Urology, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Upping the Ante in the Treatment of Gastrointestinal Cancer.
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Department of Radiation Oncology, Miami Cancer Institute, Miami, Florida.
Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern.
Curr Opin Microbiol
June 2024
Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA 02118, USA. Electronic address:
SARS-CoV-2 exhibits a remarkable capability to subvert the host antiviral innate immune system. This adeptness is orchestrated by viral proteins, which initially attempt to obstruct the activation of the antiviral immune program and then act as a fail-safe mechanism to mitigate the downstream effects of the activated immune response. This dual strategy leads to delayed expression and enfeebled action of type-I and -III interferons at the infection site, enabling the virus to replicate extensively in the lungs and subsequently disseminate to other organs.
View Article and Find Full Text PDFTattooing as a phenotypic gambit.
Am J Biol Anthropol
September 2023
Department of Anthropology, Baylor University, Waco, Texas, 76798, USA.
Objectives: Tattooing is not an evolved behavior, but it may be a phenotypic gambit to highlight immunological health. Phenotypic gambits are traits or behaviors that appear costly but occur at high rates as a honing process of natural selection not constrained by genetics. Tattooing is an ancient practice that is increasing in popularity worldwide, but it involves wounding the body, which seems counterintuitive because it challenges the immune system and makes one more susceptible to infection.
View Article and Find Full Text PDFUpping the ante on mammalian antiviral RNA interference.
Cell Host Microbe
September 2021
Division of Gastroenterology and Center for the Study of Inflammatory Bowel Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:
SARS-CoV-2 has mutually illuminated our collective knowledge and knowledge gaps, particularly in antiviral defense and therapeutic strategies. A recent study in Science (Poirier et al., 2021) uncovers an ancient antiviral mechanism that mammals utilize to suppress viruses, including SARS-CoV-2 and Zika virus, that could have broad implications for therapeutic strategies.
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