We investigate algorithmic methods to tackle the following problem: Given a system of parametric ordinary differential equations built by a biological model, does there exist ranges of values for the model parameters and variables which are both meaningful from a biological point of view and where oscillating trajectories, can be found? We show that in the common case of polynomial vector fields known criteria excluding the existence of non-constant limit cycles lead to quantifier elimination problems over the reals.We apply these criteria to various models that have been previously investigated in the context of algebraic biology.
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http://dx.doi.org/10.1007/s11538-010-9618-0 | DOI Listing |
Eur J Pediatr
January 2025
Division of Policy Evaluation, Department of Health Policy, Research Institute, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Purpose: This systematic review analyzes economic evaluations of newborn screening for congenital cytomegalovirus (cCMV) infection to identify key factors influencing cost-effectiveness and differences in methodological approaches.
Methods: Following a pre-registered PROSPERO protocol (CRD42023441587), we conducted a comprehensive literature search across multiple databases on July 4, 2024. The review included both full economic evaluations (cost and outcomes) and partial economic evaluations (cost only).
J Pediatr Urol
December 2024
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China. Electronic address:
Introduction: The incidence of kidney stones in children has steadily increased in recent years. Miniaturized percutaneous nephrolithotomy (PCNL) techniques, such as micro-PCNL(4.85Fr) and ultramini-PCNL(<15Fr), have become increasingly prevalent in pediatric kidney stone treatment due to their high stone clearance rate and low complication rate.
View Article and Find Full Text PDFJ Pediatr Nurs
January 2025
University of Newcastle, Australia; Centre for Transformative Nursing, Midwifery, and Health Research: A JBI Centre of Excellence, Australia.
Objective: This review aims to investigate parents' preference for and use of Ibuprofen and Paracetamol in managing and treating children's fevers as well as the factors influencing their decision-making and practices.
Introduction: Parents globally face concern over managing children's fever, seeking relief while ensuring safety, often relying on accessible medications like Paracetamol and Ibuprofen.
Inclusion Criteria: The review included quantitative studies involving parents and caregivers managing fever in children aged 0-17 years.
BMJ Open
January 2025
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Objective: Physical activity (PA) has been generally recognised as beneficial for health. The effect of a change in PA on kidney biomarkers in healthy individuals without kidney disease remains unclear. This manuscript synthesised the evidence of the association of changes in PA with kidney biomarkers in the general population free from kidney disease.
View Article and Find Full Text PDFBMJ
January 2025
Department of Epidemiology, Erasmus MC University Medical Centre, Rotterdam, Netherlands
Objective: To summarise available evidence on time to nursing home admission and death among people with dementia, and to explore prognostic indicators.
Design: Systematic review and meta-analysis.
Data Sources: Medline, Embase, Web of Science, Cochrane, and Google Scholar from inception to 4 July 2024.
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