Université Paris-Sud, Laboratoire de Synthèse de Biomolécules, Institut de Chimie Moléculaire et des Matériaux d'Orsay, F-91405 Orsay, France.
Published: February 2011
AI Article Synopsis
Article Abstract
Tandem catalysis by using iron(III) chloride hexahydrate leads to carbohydrate building blocks displaying an orthogonal protecting group pattern as illustrated by the regioselective protection of trehalose and maltose disaccharides.
The increasing popularity of the dihydrouracil motif in cereblon (CRBN) recruiting proteolysis-targeting chimeras (PROTACs) has necessitated the development of a facile, cost-effective, and high-yielding method for its introduction into molecules. To that end, we disclose herein an N-1 selective Pd-catalyzed cross-coupling of dihydrouracil with aryl electrophiles to provide access to medicinally relevant scaffolds in a single step. This approach exhibits excellent functional group tolerance and broad applicability to an abundance of (hetero)aryl halides and phenol derivatives and utilizes readily available catalyst/ligand systems.
Key Laboratory of Functional Molecular Engineering of Guangdong Province, State Key Laboratory of Luminescent Materials and Devices, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
A novel strategy for the synthesis of various isochromeno[4,3-]quinolines via palladium-catalyzed tandem cyclization of functional diarylalkynes with isocyanides has been developed. This approach features excellent chemo- and regioselectivities as well as good functional group tolerance. Notably, 6-phenylimino-6-isochromeno[4,3-]quinolin-11-amines and 11-amino-6-isochromeno[4,3-]quinolin-6-ones can be selectively constructed by employing different protecting groups of functional diarylalkynes.
A series of sulfonamido-substituted oxime-ethers have been synthesized by the reaction of donor-acceptor aziridines with aldo- and keto-oximes through C-C bond cleavage. Nucleophilic attack by an oxime hydroxyl group on the -generated azomethine ylide rather than the routine cycloaddition reaction draws the novelty of the developed methodology. Selective protection of the oxime hydroxyl group is observed in the presence of phenolic -OH, which made the protocol enriched.
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guizhou University, Guiyang 550025, China.
In the chemical synthesis or modification of saccharides, regioselective protection of the many similar OH groups in saccharides is necessary but remains a major challenge. In particular, the regio- and stereoselective conversion of C(1,2)-OH has great synthetic potential in carbohydrate synthesis but has largely remained untapped. Here, an in situ proton-producing system mediated by boronic acid was found and employed for site-selective ketalization of various unprotected saccharides.
This research outlines an integrated experimental and theoretical strategy for converting Pistachio-shells by hydrothermal carbonization into a bimetallic magnetic hydrochar (BMHC), for effective adsorptive-degradation of organic pollutants. Environmental sustainability of BMHC is supported by life cycle assessment(LCA). Adsorption experiments showed rapid and efficient dye (MB, CV) and antibiotic (TC) removal within 50 min, with >97% efficiency.
