AI Article Synopsis
- Mycoplasma pneumoniae (Mp) is linked to pneumonia and asthma, but the exact mechanisms of this relationship are not well understood.
- Researchers conducted a study on mice to explore how the immune system responds to Mp, finding that it triggers the movement of immune cells, particularly macrophages, to the lungs.
- Depletion of macrophages hindered the body's ability to clear Mp, suggesting that the MyD88 protein plays a crucial role in the immune response by activating signaling pathways necessary for effective macrophage function against Mp.
Article Abstract
Mycoplasma pneumoniae (Mp), a common cause of pneumonia, is associated with asthma; however, the mechanisms underlying this association remain unclear. We investigated the cellular immune response to Mp in mice. Intranasal inoculation with Mp elicited infiltration of the lungs with neutrophils, monocytes and macrophages. Systemic depletion of macrophages, but not neutrophils, resulted in impaired clearance of Mp from the lungs. Accumulation and activation of macrophages were decreased in the lungs of MyD88(-/-) mice and clearance of Mp was impaired, indicating that MyD88 is a key signaling protein in the anti-Mp response. MyD88-dependent signaling was also required for the Mp-induced activation of NFκB, which was essential for macrophages to eliminate the microbe in vitro. Thus, MyD88-NFκB signaling in macrophages is essential for clearance of Mp from the lungs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009709 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014417 | PLOS |
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