In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat.

J Clin Invest

Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

Published: October 1990

It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin beta-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC296873PMC
http://dx.doi.org/10.1172/JCI114849DOI Listing

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