In the title compound, C(11)H(9)BrN(2)O, the mol-ecules are linked into R(2) (2)(8) dimers by paired N-H⋯O hydrogen bonds and these dimers are further stacked into columns along the c axis by π-π inter-actions between pyrazinone rings [centroid-centroid distance = 3.544 Å; the dihedral angle between the planes of these rings is 7.51 (16)°]. The title compound is a precursor for agents with potential use as pharmaceuticals.
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http://dx.doi.org/10.1107/S1600536808003073 | DOI Listing |
Arch Pharm (Weinheim)
January 2025
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
New derivatives 6a-m with benzimidazole-indole-amide scaffold were developed, synthesized, and assessed for potential inhibitory effects on α-glucosidase and acetylcholinesterase (AChE). These compounds were synthesized by various amine derivatives. With the exception of two compounds, the α-glucosidase inhibitory activities of the title derivatives were more than that of the positive control acarbose.
View Article and Find Full Text PDFEFSA J
December 2024
Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia Universidad de Sevilla Sevilla Spain.
Lately, the entire society's focus has turned towards consuming more natural food products and the production of chemicals obtained utilising green technologies. The use of chemicals as food additives is a concern for consumers. For this reason, the search for natural and more sustainable additives is a key step to control food risks while meeting consumers' requirements.
View Article and Find Full Text PDFIUCrdata
October 2024
Nelson Mandela University, Summerstrand Campus, Department of Chemistry, University Way, Summerstrand, PO Box 77000, Port Elizabeth, 6031, South Africa.
The title compound, CHO, is an α-hy-droxy-carb-oxy-lic acid whose ortho-rhom-bic polymorph has been reported earlier [Qiu (2007 ▸). , , 1819-1824]. The asymmetric unit contains two complete mol-ecules.
View Article and Find Full Text PDFThe title compound, CHClNO, is significantly distorted from planarity, with a twist angle between the planes through the hy-droxy-benzene and acetamide groups being 23.5 (2)°. This conformation is supported by intra-molecular C-H⋯O and N-H⋯Cl contacts.
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October 2024
Département de Chimie, Université de Montréal, Complexe des sciences, 1375, Avenue Thérèse-Lavoie-Roux, Montréal, Québec H2V 0B3, Canada.
The title compound, CHBrNO, crystallizes with two similar mol-ecules in the asymmetric unit. The extended structure features dimers linked by pairs of N-H⋯O and C-H⋯O hydrogen bonds. The HNCNO moiety of the title compound shows delocalization over the N-C-N part, as evidenced by the similar C-N bond distances.
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