AI Article Synopsis
- Pleomorphic giant cell pancreatic cancer is a rare and aggressive type of pancreatic cancer that presents differently than more common forms, as seen in a unique case involving a cystic lesion and a serous cystadenoma.
- A 44-year-old man with a history of alcoholism initially showed symptoms that led to a misdiagnosis of a pancreatic pseudocyst, and while he improved with conservative treatment, follow-up scans later revealed the presence of pleomorphic giant cell carcinoma.
- This case underscores the importance of proper diagnosis and management of pancreatic cystic lesions and suggests that surgical intervention may be more effective than conservative treatment for atypical presentations.
Article Abstract
Introduction: Pleomorphic giant cell pancreatic cancer is a very rare and aggressive pancreatic neoplasm. A case of pleomorphic giant cell pancreatic cancer presenting as a cystic lesion and in association with a serous cystadenoma presents a unique case which has not been described before.
Case Presentation: A 44-year-old alcoholic man presented with abdominal pain, vomiting, and weight loss. Initially, imaging suspected a pancreatic pseudocyst measuring 4.2 cm. Endoscopic ultrasound- (EUS-) guided fine-needle aspiration revealed a serous cystadenoma. With conservative intervention only (fluid resuscitation, analgesia, and antiemetics) the patient improved and was discharged under close observation. Follow-up scan at four months revealed minimal change. Three months later, he was admitted acutely. Repeat scans demonstrated mild cyst enlargement with new liver lesions. Laparoscopic biopsy revealed pleomorphic giant cell carcinoma with the organ of origin the pancreas.
Conclusion: This unusual case highlights the challenges in managing pancreatic cystic lesions and emphasizes the importance of considering less common forms of pancreatic cystic masses when the findings are atypical for the presentation. Surgical excision in these cases over conservative steps may be the most appropriate management.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010638 | PMC |
| http://dx.doi.org/10.1155/2010/627360 | DOI Listing |
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