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Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model. | LitMetric

AI Article Synopsis

  • Cell-cell and cell-matrix interactions are crucial for understanding tumor growth and cancer spread, making biomimetic 3D models essential for studying these processes in vitro.
  • The study focused on how prostate cancer cells interact with human osteoblasts in a tissue-engineered bone model, revealing important biochemical changes linked to cancer metastasis.
  • These findings suggest that the 3D model can enhance our understanding of bone metastasis mechanisms and could be instrumental for future drug development and screening efforts.

Article Abstract

Cell-cell and cell-matrix interactions play a major role in tumor morphogenesis and cancer metastasis. Therefore, it is crucial to create a model with a biomimetic microenvironment that allows such interactions to fully represent the pathophysiology of a disease for an in vitro study. This is achievable by using three-dimensional (3D) models instead of conventional two-dimensional (2D) cultures with the aid of tissue engineering technology. We are now able to better address the complex intercellular interactions underlying prostate cancer (CaP) bone metastasis through such models. In this study, we assessed the interaction of CaP cells and human osteoblasts (hOBs) within a tissue engineered bone (TEB) construct. Consistent with other in vivo studies, our findings show that intercellular and CaP cell-bone matrix interactions lead to elevated levels of matrix metalloproteinases, steroidogenic enzymes and the CaP biomarker, prostate specific antigen (PSA); all associated with CaP metastasis. Hence, it highlights the physiological relevance of this model. We believe that this model will provide new insights for understanding of the previously poorly understood molecular mechanisms of bone metastasis, which will foster further translational studies, and ultimately offer a potential tool for drug screening.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946051PMC
http://dx.doi.org/10.4161/org.6.3.12041DOI Listing

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