Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro, and the enzyme is shown to have relaxed substrate specificity, allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060661 | PMC |
| http://dx.doi.org/10.1038/nchembio.509 | DOI Listing |
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