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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Clearwater, FL, USA.
Background: Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD) are characterized by abnormal aggregation and deposition of tau proteins in neurons and supporting brain cells. The underlying pathophysiology of these 4R-tauopathy disorders remains unclear. In Alzheimer's disease (AD), a related tauopathy, vesicle trafficking deficits, and impaired protein clearance are observed early in disease progression.
View Article and Find Full Text PDFMolecular insights into septin 2 protein in rohu (Labeo rohita): Revealing expression dynamics, antimicrobial activity and functional characteristics.
Int J Biol Macromol
December 2024
National Referral Laboratory for Freshwater Fish Diseases, Fish Health Management Division, ICAR-Central Institute of Freshwater Aquaculture (CIFA), Kausalyaganga, Bhubaneswar 751002, India. Electronic address:
Septins are evolutionarily conserved GTP-binding proteins mediating innate immunity, autophagy and inflammation in higher animals; however, they are yet to be fully characterized in fish. The study encompasses cloning of complete septin 2 cDNA from the rohu carp (Labeo rohita) that consisted of an open reading frame of 1050 bp and phylogenetic amino acid similarity of 99.43 % to cyprinid Onychostoma macrolepis.
View Article and Find Full Text PDFIn Saccharomyces cerevisiae cells, the bulk of mitochondrial DNA (mtDNA) replication is mediated by the replicative high-fidelity DNA polymerase γ. However, upon UV irradiation low-fidelity translesion polymerases: Polη, Polζ and Rev1, participate in an error-free replicative bypass of UV-induced lesions in mtDNA. We analysed how translesion polymerases could function in mitochondria.
View Article and Find Full Text PDFItaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane.
Signal Transduct Target Ther
December 2024
National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China.
Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune response and pathogen infection. However, its involvement in viral infection and underlying mechanisms remain incompletely understood.
View Article and Find Full Text PDFThe potential role of vesicle transport-related small GTPases rabs in abiotic stress responses.
Plant Physiol Biochem
December 2024
Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River (Ministry of Education)/College of Horticulture and Landscape Architecture, Southwest University, Chongqing, 400715, China; State Cultivation Base of Crop Stress Biology for Southern Mountainous Land of Southwest University/Academy of Agricultural Sciences of Southwest University, Chongqing, 400715, China. Electronic address:
Rab GTPases are a class of small GTP-binding proteins, play crucial roles in the membrane transport machinery with in eukaryotic cells. They dynamically regulate the precise targeting and tethering of transport vesicles to specific compartments by transitioning between active and inactive states. In plants, Rab GTPases are classified into eight distinct subfamilies: Rab1/D, Rab2/B, Rab5/F, Rab6/H, Rab7/G, Rab8/E, Rab11/A, and Rab18/C.
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