Oral nimodipine inhibits the ovarian cycle in mice.

Fertil Steril

Toronto Centre for Advanced Reproductive Technology, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.

Published: March 2011

Nimodipine, a calcium-channel blocker that can cross the blood-brain barrier, has been shown to inhibit pulsatile GnRH release in vitro. We now show that oral nimodipine can effectively inhibit the ovarian cycle in mice in a dose-related manner.

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Source
http://dx.doi.org/10.1016/j.fertnstert.2010.12.008DOI Listing

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