Nimodipine, a calcium-channel blocker that can cross the blood-brain barrier, has been shown to inhibit pulsatile GnRH release in vitro. We now show that oral nimodipine can effectively inhibit the ovarian cycle in mice in a dose-related manner.
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http://dx.doi.org/10.1016/j.fertnstert.2010.12.008 | DOI Listing |
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