We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying sign or symptom or paraclinical abnormality despite extensive work-up performed in the context of his immunocompromised state. Symptoms disappeared after 10 days and a diagnosis of Puumala infection was made retrospectively on a serological basis. The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcv.2010.11.016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- Research conducted on 3,400 febrile patients in Peru between 2020-2021 revealed a positive case of Rio Mamore hantavirus, highlighting the endemic presence of this virus in the region.
- Genetic analysis showed a strong similarity to past rodent-associated hantavirus cases from Loreto, indicating ongoing circulation.
- Findings suggest the need for enhanced hantavirus diagnostics and surveillance in Peru and Latin America due to the detection of multiple distinct hantavirus strains.
Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection.
Hum Mol Genet
November 2024
Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland.
Article Synopsis
- Puumala virus (PUUV) can lead to serious illnesses like Hemorrhagic Fever with Renal Syndrome, but the genetic factors affecting disease severity in humans are not well understood.
- A genome-wide association study using data from 2227 cases helped identify significant associations at the Human Leukocyte Antigen (HLA) locus and the ERAP1 gene, which are important for immune response.
- The study found a specific genetic variant (rs26653) in the ERAP1 gene and identified associations with several HLA alleles that suggest how these genetic factors may influence susceptibility to severe PUUV infections.
Circulating mucosal-like IgA responses increase with severity of Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome.
Front Immunol
November 2024
Viral Zoonosis Research Unit, Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Old World Orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS) characterized by increased vascular permeability and acute kidney injury (AKI). Despite the systemic nature of the disease, the virus enters humans through inhalation and therefore initially encounters the immunoglobulin class A (IgA) dominated mucosal immune system. Herein, we characterized systemic IgA responses and their potential relationship to the mucosal immune activation by examining blood samples obtained from patients hospitalized due to acute Puumala orthohantavirus infection.
View Article and Find Full Text PDFIdentification and validation of cross-reactivity of anti-Thailand orthohantavirus nucleocapsid peptides.
Hum Immunol
November 2024
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India. Electronic address:
A Thailand orthohantavirus (THAIV) is endemic in Southeast Asia. This assumption is supported by isolation of THAIV from local small mammals. Also, anti-orthohantavirus antibodies were detected in human serum.
View Article and Find Full Text PDFReplication kinetics of pathogenic Eurasian orthohantaviruses in human mesangial cells.
Virol J
October 2024
Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, D-69120, Heidelberg, Germany.
Background: Eurasian pathogenic orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS) characterized by acute kidney injury (AKI). The virulence of orthohantaviruses varies enormously and direct infection of different renal cell types contribute to pathogenesis. Glomerular mesangial cells play an essential role in the interplay between kidney cells and proper kidney function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!