This paper describes a new method for the classification of neuromuscular disorders based on the analysis of scalograms determined by the Symlet 4 wavelet technique. The approach involves isolating single motor unit action potentials (MUAPs), computing their scalograms, taking the maximum values of the scalograms in five selected scales, and averaging across MUAPs to give a single 5-dimensional feature vector per subject. After SVM analysis, the vector is reduced to a single decision parameter, called the Wavelet Index, allowing the subject to be assigned to one of three groups: myogenic, neurogenic or normal. The software implementation of the method described above created a tool supporting electromyographic (EMG) examinations. The method is characterized by a high probability for the accurate diagnosis of muscle state. The method produced 5 misclassifications out of 800 examined cases (total error of 0.6%).
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.cmpb.2010.12.006 | DOI Listing |
BioDrugs
January 2025
Department of Neurology, Neuroscience Clinical Research Center (NCRC) and Integrated Myasthenia Gravis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Charitéplatz 1, Germany.
Myasthenia gravis (MG) is a rare autoimmune disease characterised by exertion-induced muscle weakness that can lead to potentially life-threatening myasthenic crises. Detectable antibodies are directed against specific postsynaptic structures of the neuromuscular junction. MG is a chronic condition that can be improved through therapies, but to date, not cured.
View Article and Find Full Text PDFPathology
December 2024
Department of Neuropathology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India. Electronic address:
Neuropathology has been in existence as a speciality in India since the 1950s. Its practice has kept pace with the developments in the field, paralleling advancements in neurosurgery and neurosciences, especially in tertiary care centres. This nationwide survey, conducted across 52 centres, provides a comprehensive analysis of diagnostic infrastructure, training opportunities, and challenges in the practice of neuropathology.
View Article and Find Full Text PDFIntroduction: Living with a chronic disease impacts many aspects of life, including the ability to participate in activities that enable interactions with others in society, that is, social participation (SP). Despite efforts to monitor the quality of care and life of chronically ill people in Belgium, no disease-specific patient-reported measures (PRMs) have been used. These tools are essential to understand SP and to develop evidence-based recommendations to support its improvement.
View Article and Find Full Text PDFNeurology
January 2025
The Dubowitz Neuromuscular Centre, Developmental Neurosciences Department, University College London, Great Ormond Street Institute of Child Health, United Kingdom.
Background And Objectives: Safety and efficacy of IV onasemnogene abeparvovec has been demonstrated for patients with spinal muscular atrophy (SMA) weighing <8.5 kg. SMART was the first clinical trial to evaluate onasemnogene abeparvovec for participants weighing 8.
View Article and Find Full Text PDFCells
January 2025
Department of Physical Medicine and Rehabilitation, University of Missouri School of Medicine, Columbia, MO 65211, USA.
Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease primarily affecting motor neurons, leading to progressive muscle atrophy and paralysis. This review explores the role of Schwann cells in ALS pathogenesis, highlighting their influence on disease progression through mechanisms involving demyelination, neuroinflammation, and impaired synaptic function. While Schwann cells have been traditionally viewed as peripheral supportive cells, especially in motor neuron disease, recent evidence indicates that they play a significant role in ALS by impacting motor neuron survival and plasticity, influencing inflammatory responses, and altering myelination processes.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!