Objective: To evaluate the effects of thiopental, propofol, and etomidate on glomerular filtration rate (GFR) measured by the use of dynamic computed tomography in dogs.
Animals: 17 healthy Beagles.
Procedures: Dogs were randomly assigned to receive 2 mg of etomidate/kg (n = 5), 6 mg of propofol/kg (7), or 15 mg of thiopental/kg (5) during induction of anesthesia; anesthesia was subsequently maintained by isoflurane evaporated in 100% oxygen. A 1 mL/kg dosage of a 300 mg/mL solution of iohexol was administered at a rate of 3 mL/s during GFR measurement. Regions of interest of the right kidney were manually drawn to exclude vessels and fatty tissues and highlight the abdominal portion of the aorta. Iohexol clearance per unit volume of the kidney was calculated by use of Patlak plot analysis.
Results: Mean ± SD weight-adjusted GFR of the right kidney after induction of anesthesia with thiopental, propofol, and etomidate was 2.04 ± 0.36 mL/min/kg, 2.06 ± 0.29 mL/min/kg, and 2.14 ± 0.43 mL/min/kg, respectively. However, no significant differences in weight-adjusted GFR were detected among the treatment groups.
Conclusions And Clinical Relevance: Results obtained for the measurement of GFR in anesthetized dogs after anesthetic induction with etomidate, propofol, or thiopental and maintenance with isoflurane did not differ significantly. Therefore, etomidate, propofol, or thiopental can be used in anesthesia-induction protocols that involve the use of isoflurane for maintenance of anesthesia without adversely affecting GFR measurements obtained by the use of dynamic computed tomography in dogs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2460/ajvr.72.1.146 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sedation Practices in Mechanically Ventilated Neurocritical Care Patients from 19 Countries: An International Cohort Study.
Neurocrit Care
January 2025
Division of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Our objective was to characterize the impact of common initial sedation practices on invasive mechanical ventilation (IMV) duration and in-hospital outcomes in patients with acute brain injury (ABI) and to elucidate variations in practices between high-income and middle-income countries.
Methods: This was a post hoc analysis of a prospective observational data registry of neurocritically ill patients requiring IMV. The setting included 73 intensive care units (ICUs) in 18 countries, with a total of 1,450 patients with ABI requiring IMV.
Comparing the Effects of Propofol and Thiopental on Human Renal HEK-293 Cells With a Focus on Reactive Oxygen Species (ROS) Production, Cytotoxicity, and Apoptosis: Insights Into Dose-Dependent Toxicity.
Cureus
November 2024
Medical Biochemistry, Harran University, Şanliurfa, TUR.
Objectives: Propofol and thiopental are widely used as hypnotic, sedative, antiepileptic, and analgesic agents in general anesthesia and intensive care; however, their side effects remain unknown. They are used for long periods and at high doses for sedation in total intravenous anesthesia (TIVA) and intensive care units. Long-term and high-dose use of these drugs can lead to accumulation in plasma and tissues, resulting in high drug concentrations and increasing the risk of potential toxicity (e.
View Article and Find Full Text PDFInfluence of the type of anaesthesia on acute kidney injury after nephrectomy: a randomised controlled trial.
Anaesthesia
November 2024
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Article Synopsis
- The study investigates the impact of maintenance anaesthetics (propofol vs. desflurane) on acute kidney injury (AKI) following nephrectomy in patients with renal cell carcinoma.
- A total of 317 patients were analyzed, with a 25% incidence of postoperative AKI, showing no significant difference between the propofol group (27%) and the desflurane group (23%).
- The conclusion suggests that the choice of anaesthetic does not influence AKI risk, indicating that future research should focus on other modifiable factors contributing to AKI in these patients.
Article Synopsis
- The study aimed to identify anesthetic agents that reduce negative outcomes during laryngeal mask airway (LMA) insertion in adult patients receiving general anesthesia.
- A network meta-analysis of 53 randomized controlled trials involving 4695 patients found that the combination of propofol and dexmedetomidine was most effective in minimizing adverse events during the procedure.
- Overall, all anesthetic combinations, except for those involving thiopental, were better than propofol alone in reducing adverse outcomes related to apnea, insertion failure, and inadequate anesthesia depth.
Unusual Resistance to Intravenous Anesthetic Drugs in a Rachipagus Infant: A Case Report.
A A Pract
November 2024
From the Department of Anaesthesiology, Pain and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
In conjoined twins when one of the twins is incompletely formed and is dependent on the healthy counterpart for survival, they are described as heteropagus (parasitic) twins. Rachipagus is a type of parasitic twin joined at the spine above the sacrum. Such neonates can present with complex problems related to anesthesia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!