AI Article Synopsis
- Croton nepetaefolius, a native Brazilian plant from the Euphorbiaceae family, contains bioactive compounds like alkaloids, diterpenes, and triterpenes that have been widely studied for their effects.
- The study focused on casbane diterpene (CD) extracted from this plant, revealing its ability to inhibit microbial growth and biofilm formation in various clinically relevant bacteria and yeasts at concentrations between 125 and 500 µg/mL.
- CD demonstrated potential as a natural remedy against infections, effectively targeting biofilm formation while having a minimal impact on bacterial growth.
Article Abstract
Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259237 | PMC |
| http://dx.doi.org/10.3390/molecules16010190 | DOI Listing |
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